INT200671

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (AKT3) Golgi apparatus (AKT3) nucleolus (AKT3)
plasma membrane (AKT3) nucleus (AKT3) cytoplasm (AKT3)
Anatomy Link Frequency
HeLa 1
AKT3 (Homo sapiens)
AKT3 - E438D (1)
Pain Link Frequency Relevance Heat
headache 2 65.12 Quite High
Migraine 2 64.36 Quite High
withdrawal 2 46.56 Quite Low
palliative 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 99.16 Very High Very High Very High
Apoptosis 102 98.68 Very High Very High Very High
Malignant Neoplastic Disease 23 92.68 High High
Hyperplasia 19 90.08 High High
Melanoma 91 82.96 Quite High
Cancer 193 82.12 Quite High
Convulsion 2 66.92 Quite High
Cluster Headache 2 65.12 Quite High
Headache 2 64.36 Quite High
Epilepsy 2 63.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of AKT3 renders cells less sensitive to apoptotic stimuli and as mentioned before; PTEN inactivation can lead to the selective activation of AKT in CMs [92].
Gene_expression (Overexpression) of AKT3 associated with apoptosis
1) Confidence 0.69 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.65 Pain Relevance 0
Mutations in AKT family members and their correlation with other gene alterations are found in endometrial carcinoma, including AKT2 (D399N), AKT2 (D32H) and AKT3 (E438D) mutations.
Gene_expression (mutations) of AKT3 (E438D) associated with endometrial cancer
2) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.49 Pain Relevance 0
and Akt3/PKB?
Gene_expression (/) of Akt3
3) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.69 Pain Relevance 0.13
Akt3 was the most abundant of Akt isoforms in the HeLa cells (Fig. 6A).
Gene_expression (abundant) of Akt3 in HeLa
4) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.06 Pain Relevance 0

General Comments

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