INT200676

Context Info Confidence 0.53 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.01 Pain Relevance 0.19

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2) carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)

AKT2 (Homo sapiens)

Pain Link Frequency Relevance Heat withdrawal 2 85.44 headache 2 55.20 Migraine 2 54.44

Disease Link Frequency Relevance Heat Apoptosis 82 91.12 Cancer 52 72.20 Convulsion 2 57.00 Cluster Headache 2 55.20 Headache 2 54.44 Epilepsy 2 54.04 Malignant Neoplastic Disease 4 35.24 Repression 4 34.80 Death 50 5.00 Cervical Cancer 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The phosphorylation of a conserved threonine residue (Thr308 in Akt1, Thr309 in Akt2 and Thr305 in Akt3), upon growth factor stimulation, is required for Akt activation, while the phosphorylation of a serine residue (Ser473 in Akt1, Ser474 in Akt2 and Ser474 in Akt3) is only required for maximal Akt activity [21,24-26].

Phosphorylation (phosphorylation) of Akt2

1) Confidence 0.53 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.43 Pain Relevance 0.04

The phosphorylation of a conserved threonine residue (Thr308 in Akt1, Thr309 in Akt2 and Thr305 in Akt3), upon growth factor stimulation, is required for Akt activation, while the phosphorylation of a serine residue (Ser473 in Akt1, Ser474 in Akt2 and Ser474 in Akt3) is only required for maximal Akt activity [21,24-26].

Phosphorylation (phosphorylation) of Akt2

2) Confidence 0.18 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.58 Pain Relevance 0.15

General Comments

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