INT200677

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 56 98.58 Very High Very High Very High
Inflammation 87 91.84 High High
withdrawal 1 74.72 Quite High
headache 1 12.52 Low Low
Migraine 1 11.76 Low Low
Inflammatory response 57 5.00 Very Low Very Low Very Low
Inflammatory stimuli 35 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 41 99.00 Very High Very High Very High
INFLAMMATION 154 91.84 High High
Cancer 26 50.00 Quite Low
Convulsion 1 14.32 Low Low
Cluster Headache 1 12.52 Low Low
Headache 1 11.76 Low Low
Epilepsy 1 11.36 Low Low
Death 25 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Cervical Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given, therefore, a quantification of the dynamics of corticosteroids and putative modes of action of CS in regulating the activity of NFkB [73], [74] we test the hypothesis that corticosteroids exert their immunosuppressive effect by enhancing the transcriptional synthesis of NF-kB's inhibitor IkBa (mRNA,IkBa).
Transcription (synthesis) of NF-kB associated with corticosteroid
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.32 Pain Relevance 0.45
In contrast, NF-kB, a transcription factor involved in promoting cell survival, is positively influenced by Akt that phosphorylates and activates IKK?
Transcription (transcription) of NF-kB
2) Confidence 0.04 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.42 Pain Relevance 0.04

General Comments

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