INT200685

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 6.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2)
carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)
Anatomy Link Frequency
HeLa 6
apoptotic cell 2
AKT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 9 6.64 Low Low
Migraine 9 5.00 Very Low Very Low Very Low
headache 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cervical Cancer 45 99.80 Very High Very High Very High
Apoptosis 369 99.52 Very High Very High Very High
Death 225 97.88 Very High Very High Very High
Cancer 234 94.68 High High
Repression 18 91.12 High High
Ovarian Cancer 18 75.76 Quite High
Malignant Neoplastic Disease 18 73.60 Quite High
Epilepsy 9 5.00 Very Low Very Low Very Low
Headache 9 5.00 Very Low Very Low Very Low
Cluster Headache 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 5C, both valproic acid and butyrate decreased the levels of Akt1 and Akt2 mRNA to a certain degree, but not significantly.
Negative_regulation (decreased) of Gene_expression (levels) of Akt2 mRNA
1) Confidence 0.38 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.25 Pain Relevance 0
We, for the first time, show that the down-regulation of Akt activity is a consequence of inhibition of Akt1 and Akt2 expression by valproic acid and butyrate.
Negative_regulation (inhibition) of Gene_expression (expression) of Akt2
2) Confidence 0.38 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.66 Pain Relevance 0
Valproic acid and butyrate repress Akt1 and Akt2 expression and induce apoptosis in HeLa cells
Negative_regulation (repress) of Gene_expression (expression) of Akt2 in HeLa associated with apoptosis
3) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 1.27 Pain Relevance 0
We show that histone deacetylase inhibitors, such as valproic acid and butyrate, impede Akt1 and Akt2 expression, which leads to Akt deactivation and apoptotic cell death.
Negative_regulation (impede) of Gene_expression (expression) of Akt2 in apoptotic cell associated with apoptosis and death
4) Confidence 0.28 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1762018 Disease Relevance 0.90 Pain Relevance 0
As shown in Fig. 1B, following 16 hours of butyrate treatment, the levels of Akt1 and Akt2 mRNA were reduced by about 70% and 50% respectively as compared to untreated control cells.
Negative_regulation (reduced) of Gene_expression (levels) of Akt2 mRNA
5) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.40 Pain Relevance 0
Taken together, these data suggest that the down-regulation of Akt activity by HDAC inhibitors, such as valproic acid and butyrate, is achieved through inhibition of gene expression of Akt1 and Akt2.


Negative_regulation (inhibition) of Gene_expression (expression) of Akt2
6) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.26 Pain Relevance 0
Treatment of HeLa cells with HDAC inhibitors such as valproic acid and butyrate leads to inhibition of Akt1 and Akt2 expression, consequently to deactivation of cellular Akt (Fig. 1 and 2).
Negative_regulation (inhibition) of Gene_expression (expression) of Akt2 in HeLa
7) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.86 Pain Relevance 0
Our study demonstrated that HDAC inhibitors, such as valproic acid and butyrate, induce apoptosis in HeLa cervical cancer cells by inhibition of gene expression of Akt1 and Akt2.
Negative_regulation (inhibition) of Gene_expression (expression) of Akt2 in HeLa associated with cervical cancer and apoptosis
8) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 1.15 Pain Relevance 0
Valproic acid treatment also reduced the levels of the Akt1 and Akt2 mRNA, but to a lesser degree (Fig. 1B).
Negative_regulation (reduced) of Gene_expression (levels) of Akt2 mRNA
9) Confidence 0.28 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.33 Pain Relevance 0

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