INT20071

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 10.89
Pain Relevance 14.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
platelet 2
cerebrospinal fluid 1
forebrain 1
rod bipolar cells 1
hypothalamus 1
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 74 100.00 Very High Very High Very High
Serotonin 206 99.96 Very High Very High Very High
antidepressant 70 99.84 Very High Very High Very High
fluoxetine 62 99.78 Very High Very High Very High
5HT 151 99.74 Very High Very High Very High
sSRI 108 99.66 Very High Very High Very High
headache 21 99.20 Very High Very High Very High
Raphe 15 98.84 Very High Very High Very High
anesthesia 1 98.60 Very High Very High Very High
Delta opioid receptors 1 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 307 99.76 Very High Very High Very High
Malignant Hyperthermia 21 99.24 Very High Very High Very High
Headache Disorders 5 99.20 Very High Very High Very High
Serotonin Syndrome 26 98.96 Very High Very High Very High
Urological Neuroanatomy 6 98.28 Very High Very High Very High
Coronary Artery Disease 14 98.12 Very High Very High Very High
Headache 35 97.92 Very High Very High Very High
Obesity 4 97.06 Very High Very High Very High
Appetite Loss 7 96.80 Very High Very High Very High
Sleep Disorders 5 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia.
Positive_regulation (stimulation) of 5-HT2 associated with anesthesia, malignant hyperthermia and serotonin
1) Confidence 0.67 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2118235 Disease Relevance 0.94 Pain Relevance 0.31
These findings suggest that 5-HT-induced NO production is mediated by both of 5-HT1B and 5-HT2B receptor activation in HCAECs.
Positive_regulation (activation) of 5-HT2
2) Confidence 0.67 Published 1998 Journal Kobe J Med Sci Section Abstract Doc Link 10036860 Disease Relevance 0 Pain Relevance 0.32
This suggests that chronic treatment by SSRIs could induce an up-regulation of the 5-HT2A receptors, and that 5-HT2A receptor down-regulation is not a common mechanism for the therapeutic effects of all serotoninergic antidepressive drugs.
Positive_regulation (up-regulation) of 5-HT2A associated with ssri
3) Confidence 0.67 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9335087 Disease Relevance 0.25 Pain Relevance 0.21
Evidence of such suppression in patients with chronic daily headache includes decreased platelet serotonin, up-regulation of 5-HT2A receptors, increased platelet nitric oxide production, and increased levels of substance P and nerve growth factor in the cerebrospinal fluid.
Positive_regulation (up-regulation) of 5-HT2A in cerebrospinal fluid associated with headache disorders, nerve growth factor, headache, serotonin and substance p
4) Confidence 0.67 Published 2002 Journal Headache Section Abstract Doc Link 12167146 Disease Relevance 0.82 Pain Relevance 1.19
Activation of these somadendritically located 5-HT2a receptors facilitates SP release.
Positive_regulation (Activation) of 5-HT2a
5) Confidence 0.67 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938661 Disease Relevance 0.07 Pain Relevance 0.24
Stimulation of 5-HT1A, 5-HT1B, 5-HT2A/2C, 5-HT3 and 5-HT4 receptors or 5-HT uptake inhibition: short- and long-term memory.
Positive_regulation (Stimulation) of 5-HT2A
6) Confidence 0.67 Published 2007 Journal Behav. Brain Res. Section Title Doc Link 17692935 Disease Relevance 0 Pain Relevance 0.38
Stimulation of the postsynaptic 5HT1A and 5HT2A receptors contributes to serotonin syndrome [41], but no single receptor is solely responsible.
Positive_regulation (Stimulation) of 5HT2A associated with serotonin
7) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2246210 Disease Relevance 0.89 Pain Relevance 0.61
The activation of postsynaptic 5-HT2A and 5-HT2C receptors may be important in the improvement of OCD symptoms after treatment with an SSRI.45 Studies in OCD patients showed blunted prolactin and cortisol responses to 5-HT2 receptor agonists.46 Enoch et al.47 recruited and genotyped 101 Caucasian OCD patients (48 females, 53 males) and 138 control subjects (77 females, 61 males) and found that the -1438A allele frequency was higher only in female OCD patients and not in male patients.
Positive_regulation (activation) of 5-HT2A associated with anxiety disorder, agonist and ssri
8) Confidence 0.67 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.87 Pain Relevance 0.19
Nitric oxide is produced via 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells.
Positive_regulation (activation) of 5-HT2 in coronary artery
9) Confidence 0.67 Published 1998 Journal Kobe J Med Sci Section Title Doc Link 10036860 Disease Relevance 0 Pain Relevance 0.31
While fluoxetine also reduced 5HT2A-R function, but to a lesser degree, imipramine increased 5HT2A-R function, which may explain why mI seems to be effective exclusively in selective serotonin reuptake inhibitor-sensitive disorders.
Positive_regulation (increased) of 5HT2A-R associated with ssri and fluoxetine
10) Confidence 0.57 Published 2004 Journal Metab Brain Dis Section Abstract Doc Link 15214506 Disease Relevance 0.29 Pain Relevance 0.63
Some of the selective serotonin reuptake inhibitors (SSRI)-induced motor side effects are mediated by stimulating 5-HT2 receptors in the basal ganglia, probably because serotonin inhibits the subsequent neuronal dopamine release.
Positive_regulation (stimulating) of 5-HT2 in neuronal associated with dopamine, serotonin and ssri
11) Confidence 0.49 Published 2003 Journal J Clin Psychopharmacol Section Abstract Doc Link 14520130 Disease Relevance 0.28 Pain Relevance 0.39
Up-regulation of 5-HT2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration.
Positive_regulation (Up-regulation) of 5-HT2 in astrocytes associated with fluoxetine
12) Confidence 0.49 Published 2002 Journal Neurochem. Res. Section Title Doc Link 11930908 Disease Relevance 0 Pain Relevance 0.48
[Changes of 5-HT2A receptor binding on platelet of patients with CAD and the effects of exercise test].
Positive_regulation ([Changes) of 5-HT2A in platelet associated with coronary artery disease
13) Confidence 0.49 Published 1997 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Title Doc Link 10453517 Disease Relevance 0.77 Pain Relevance 0.08
It is concluded that 5-HT-evoked contraction of human coronary arteries is most probably mediated via the activation of both 5-HT1B and 5-HT2A receptors.
Positive_regulation (activation) of 5-HT2
14) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0 Pain Relevance 0.15
At day 4, this 5-HT2B-mediated inhibition of the 5-HT1B/1D function can be blocked upon concomitant 5-HT2A activation although a 5-HT2A/PLA2 positive coupling was evidenced.
Positive_regulation (activation) of 5-HT2A
15) Confidence 0.49 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9651340 Disease Relevance 0 Pain Relevance 0.07
In preparation for testing the validity of platelets as a model system for changes in 5-HT2 receptors during antidepressant drug treatment, mianserin (40 mg daily), was given to five human volunteers for five days, and platelets were collected on days 0, 1, 6, and 8. 5-HT2 receptor affinity and density were measured by specific binding of 125I-LSD, with and without an excess of spiperone. 5-HT uptake site affinity and density were determined by 3H-paroxetine binding, with and without an excess of fluoxetine.
Positive_regulation (changes) of 5-HT2 in platelets associated with antidepressant and fluoxetine
16) Confidence 0.49 Published 1993 Journal Life Sci. Section Abstract Doc Link 8326822 Disease Relevance 0 Pain Relevance 0.39
Ongoing clinical evaluation with MDL 100,907 will test the hypothesis that 5-HT2A receptor antagonism is sufficient for antipsychotic activity in humans.
Positive_regulation (sufficient) of 5-HT2A
17) Confidence 0.49 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627580 Disease Relevance 0.16 Pain Relevance 0.26
Based on these findings, we suggest that up-regulation of 5HT2 serotonin receptors may be a possible mechanism of headache transformation in patients with AIH.
Positive_regulation (up-regulation) of 5HT2 associated with headache and serotonin
18) Confidence 0.49 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8902250 Disease Relevance 1.25 Pain Relevance 1.62
Structural modifications of N- and C-linked (principally hydantoin) analogues at the 5-position were synthesized and their pharmacological activities were utilized to deduce significant steric and electrostatic requirements of the 5-HT1D and 5-HT2A receptor subtypes.
Positive_regulation (requirements) of 5-HT2A
19) Confidence 0.49 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7658443 Disease Relevance 0.07 Pain Relevance 0.12
The presence of 5-HT1D alpha, 5-HT1D beta, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT7 receptor subtype messenger RNA was detected in dorsal root ganglia from three of the four subjects. 5-HT1A receptor subtype messenger RNA was detected in one of the four subjects.
Positive_regulation (presence) of 5-HT2A in dorsal root ganglia
20) Confidence 0.49 Published 1997 Journal Neuroscience Section Abstract Doc Link 9316030 Disease Relevance 0.22 Pain Relevance 0.49

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