INT20072

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.96
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
cerebrospinal fluid 2
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 22 99.96 Very High Very High Very High
sSRI 11 99.86 Very High Very High Very High
substance P 4 99.56 Very High Very High Very High
headache 6 99.20 Very High Very High Very High
Nerve growth factor 1 98.92 Very High Very High Very High
anesthesia 1 98.60 Very High Very High Very High
agonist 5 97.32 Very High Very High Very High
gABA 4 96.16 Very High Very High Very High
central sensitization 1 95.60 Very High Very High Very High
Pain 2 92.92 High High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 9 99.96 Very High Very High Very High
Anxiety Disorder 209 99.76 Very High Very High Very High
Headache Disorders 4 99.20 Very High Very High Very High
Psychosis 1 94.08 High High
Pain 2 92.92 High High
Syndrome 5 90.56 High High
Nociception 2 89.88 High High
Depression 5 88.72 High High
Muscle Rigidity 1 85.32 High High
Acidosis 1 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that chronic treatment by SSRIs could induce an up-regulation of the 5-HT2A receptors, and that 5-HT2A receptor down-regulation is not a common mechanism for the therapeutic effects of all serotoninergic antidepressive drugs.
Positive_regulation (induce) of Positive_regulation (up-regulation) of 5-HT2A associated with ssri
1) Confidence 0.67 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9335087 Disease Relevance 0.25 Pain Relevance 0.21
Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia.
Positive_regulation (induces) of Positive_regulation (stimulation) of 5-HT2 associated with anesthesia, malignant hyperthermia and serotonin
2) Confidence 0.49 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2118235 Disease Relevance 0.94 Pain Relevance 0.31
Activation of these somadendritically located 5-HT2a receptors facilitates SP release.
Positive_regulation (facilitates) of Positive_regulation (Activation) of 5-HT2a
3) Confidence 0.49 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938661 Disease Relevance 0.07 Pain Relevance 0.24
It is concluded that 5-HT-evoked contraction of human coronary arteries is most probably mediated via the activation of both 5-HT1B and 5-HT2A receptors.
Spec (probably) Positive_regulation (mediated) of Positive_regulation (activation) of 5-HT2
4) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0 Pain Relevance 0.15
Evidence of such suppression in patients with chronic daily headache includes decreased platelet serotonin, up-regulation of 5-HT2A receptors, increased platelet nitric oxide production, and increased levels of substance P and nerve growth factor in the cerebrospinal fluid.
Positive_regulation (increased) of Positive_regulation (up-regulation) of 5-HT2A in cerebrospinal fluid associated with headache disorders, nerve growth factor, headache, serotonin and substance p
5) Confidence 0.49 Published 2002 Journal Headache Section Abstract Doc Link 12167146 Disease Relevance 0.82 Pain Relevance 1.23
The activation of postsynaptic 5-HT2A and 5-HT2C receptors may be important in the improvement of OCD symptoms after treatment with an SSRI.45 Studies in OCD patients showed blunted prolactin and cortisol responses to 5-HT2 receptor agonists.46 Enoch et al.47 recruited and genotyped 101 Caucasian OCD patients (48 females, 53 males) and 138 control subjects (77 females, 61 males) and found that the -1438A allele frequency was higher only in female OCD patients and not in male patients.
Positive_regulation (important) of Positive_regulation (activation) of 5-HT2A associated with anxiety disorder, agonist and ssri
6) Confidence 0.49 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.88 Pain Relevance 0.19

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