INT200734

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 3.20
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
nucleus 1
HIST2H3C (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 96.52 Very High Very High Very High
Leflunomide 60 95.92 Very High Very High Very High
methotrexate 56 93.52 High High
rheumatoid arthritis 308 89.44 High High
Osteoarthritis 213 84.44 Quite High
Arthritis 8 50.00 Quite Low
cINOD 28 49.68 Quite Low
corticosteroid 12 33.28 Quite Low
Inflammation 77 16.32 Low Low
Pain 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 488 98.36 Very High Very High Very High
Breast Cancer 14 96.56 Very High Very High Very High
Hematologic Neoplasms 3 95.80 Very High Very High Very High
Cancer 58 95.32 Very High Very High Very High
Disease 135 94.00 High High
Frailty 136 84.44 Quite High
Disease Progression 24 66.64 Quite High
Autoimmune Disease 28 58.64 Quite High
Stress 5 54.80 Quite High
INFLAMMATION 78 49.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the ability of valproic acid to hyperacetylate H3 and H4 histones and to inhibit HDAC has been also demonstrated in the peripheral blood of patients with hematological neoplasms [10], [9].
Phosphorylation (hyperacetylate) of H3 in blood associated with hematologic neoplasms
1) Confidence 0.25 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.34 Pain Relevance 0
We found that NAPA can also inhibit H3 phosphorylation by IKK?
Phosphorylation (phosphorylation) of H3
2) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
-phosphorylated substrates is the histone H3, which is subsequently acetylated [25].
Phosphorylation (phosphorylated) of H3
3) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
Interestingly, GlcN does not inhibit histone H3 phosphorylation (Figure 6b).


Phosphorylation (phosphorylation) of H3
4) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.05 Pain Relevance 0
, after translocating into the nucleus, phosphorylates histone H3, thereby permitting the transcription of several genes under NF-?
Phosphorylation (phosphorylates) of H3 in nucleus
5) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
-dependent phosphorylation of histone H3 and indeed found that this is the case (Figure 6a).
Phosphorylation (phosphorylation) of H3
6) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
Moreover, the extent of phosphorylation of H3 and AKT in the CD4+,CD8+ and CD20+ cells of the PB of ERA patients also directly correlated with DAS28 (Figure 5).


Phosphorylation (phosphorylation) of H3 associated with rheumatoid arthritis
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.78 Pain Relevance 0.07
H3 phosphorylation is associated with gene transcription and cell division [36] and the correlation with MDGA score or DAS may point toward expansion of these cell populations.
Phosphorylation (phosphorylation) of H3
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.90 Pain Relevance 0.24
We identified correlations between the extent of phosphoryation of AKT and H3 in the CD4+, CD8+ and CD20+ PB cells of ERA patients and their MDGA score and DAS.
Phosphorylation (phosphoryation) of H3 associated with rheumatoid arthritis
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.13 Pain Relevance 0.29
Our analysis revealed significant reductions in the phosphorylation of AKT and H3 in the PBMC CD4+ cells (Figure S9) but no change in the reduction in p-STAT1 observed in the CD20+ cells.
Phosphorylation (phosphorylation) of H3
10) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.18

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