INT200738

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.65
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mononuclear cells 1
HIST2H4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 222 94.88 High High
Pain 44 88.24 High High
IPN 12 83.84 Quite High
Inflammation 20 79.48 Quite High
Central nervous system 11 72.60 Quite High
Face pain 4 45.64 Quite Low
tolerance 1 32.68 Quite Low
cytokine 17 31.52 Quite Low
Spinal cord 4 5.96 Low Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 1 99.84 Very High Very High Very High
Cancer 171 99.56 Very High Very High Very High
Hypocalcemia 2 99.48 Very High Very High Very High
Hypoalbuminemia 4 98.72 Very High Very High Very High
Vomiting 61 98.04 Very High Very High Very High
Adenocarcinoma 39 97.40 Very High Very High Very High
Anorexia 8 97.32 Very High Very High Very High
Fatigue 37 96.92 Very High Very High Very High
Neurologic Gait Disorders 2 94.80 High High
Anaplastic Astrocytoma 16 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same has been observed regarding H3 and H4 histone hyperacetylation and/or inhibition of HDAC activity by a number of agents including valproic acid [48].
Gene_expression (hyperacetylation) of H4 histone
1) Confidence 0.18 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.09 Pain Relevance 0
H4 cells stably expressing I?
Gene_expression (expressing) of H4
2) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.59 Pain Relevance 0.63
treatment in either H4 or H4 I?
Gene_expression (either) of H4
3) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.07 Pain Relevance 0.28
Histones H3 and H4 were deacetylated in gastric cancer cell lines showing aberrant methylation of CHFR, a mitotic checkpoint gene, suggesting a role for histone deacetylation in methylation-dependent gene silencing (Satoh et al. 2003).
Gene_expression (deacetylated) of H4 associated with stomach cancer
4) Confidence 0.11 Published 2007 Journal Bioinform Biol Insights Section Body Doc Link PMC2323355 Disease Relevance 0.97 Pain Relevance 0
Levels of histone H3 and H4 acetylation in PBMCs increased.
Gene_expression (Levels) of H4
5) Confidence 0.09 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.00 Pain Relevance 0
Histone H3/H4 acetylation, p21 expression, and caspase-3 activation can be induced by MS-275 in bone marrow mononuclear cells.
Gene_expression (acetylation) of H4 in mononuclear cells
6) Confidence 0.08 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.58 Pain Relevance 0
There are several types of histone of which H2A, H2B, H3 and H4 are the core histones that form the nucleosome, and H1 and H5 are the linker histones.
Gene_expression (types) of H4
7) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866484 Disease Relevance 0.34 Pain Relevance 0

General Comments

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