INT200750

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 24
Disease Relevance 6.52
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rho) Golgi apparatus (Rho) plasma membrane (Rho)
signal transducer activity (Rho)
Anatomy Link Frequency
photoreceptor 3
eye 2
fat 1
amacrine cells 1
neurons 1
Rho (Mus musculus)
Rho - P27L (1) Rho - E113Q (1)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
Neurotransmitter 3 91.60 High High
TRP channel 1 90.16 High High
bDMF 6 87.32 High High
Neuritis 2 73.60 Quite High
addiction 15 72.36 Quite High
Glutamate 4 71.04 Quite High
Inflammation 30 66.08 Quite High
Pain 1 64.56 Quite High
imagery 5 64.40 Quite High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Targeted Disruption 71 99.88 Very High Very High Very High
Retinal Degeneration 84 99.60 Very High Very High Very High
Ganglion Cysts 36 99.52 Very High Very High Very High
Retina Disease 111 98.84 Very High Very High Very High
Optic Nerve Injuries 2 93.32 High High
Glaucoma 8 91.68 High High
Neurodegenerative Disease 4 91.44 High High
Disease 38 90.52 High High
Ocular Hypertension 7 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The delay between photon absorption by rhodopsin and activation of the receptor current is only 20?
Gene_expression (absorption) of rhodopsin
1) Confidence 0.65 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0.06 Pain Relevance 0.11
M WTS ODN had a significant effect on rhodopsin expression in PN28 rd1 mice, indicating increased photoreceptor survival.
Gene_expression (expression) of rhodopsin in photoreceptor
2) Confidence 0.46 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Rhodopsin immunostaining on eye sections at PN33: Confirmatory experiments
Gene_expression (immunostaining) of Rhodopsin in eye
3) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
However, rhodopsin-expressing cells were much more numerous than those expressing ?
Gene_expression (numerous) of rhodopsin
4) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Rhodopsin is the most abundantly-expressed photoreceptor-specific protein and is frequently used as a marker to detect the existence of rod photoreceptor cells [45-47].
Gene_expression (expressed) of Rhodopsin in photoreceptor
5) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Rhodopsin immunohistochemistry on PN28 eye sections
Gene_expression (immunohistochemistry) of Rhodopsin in eye
6) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0.03
Likewise, when rats expressing the P23H or S334ter rhodopsin transgenes were raised on the SFO diet, which reduced their ROS DHA by 50%, there was no exacerbation of rod photoreceptor cell loss [29].
Gene_expression (expressing) of rhodopsin in photoreceptor cell
7) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927381 Disease Relevance 0.44 Pain Relevance 0
The percentage of rhodopsin positive M6a-overexpressing cells was not significantly, but few times higher than that of control cells (Figure 2B).
Gene_expression (-) of rhodopsin
8) Confidence 0.29 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.15 Pain Relevance 0
Statistical analysis was not possible at 28 weeks of age as no rhodopsin was detectable in Fat1+/VPP+ mice at this age.


Neg (no) Gene_expression (detectable) of rhodopsin
9) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927381 Disease Relevance 0.39 Pain Relevance 0
VPP mice have reduced levels of rhodopsin and amplitudes of a- and b-waves of their scotopic ERG compared to nontransgenic littermates [36].
Gene_expression (levels) of rhodopsin
10) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927381 Disease Relevance 0.54 Pain Relevance 0
High levels of retinal docosahexaenoic acid do not protect mice expressing the VPP rhodopsin mutation from retinal degeneration.



Gene_expression (expressing) of rhodopsin associated with retinal degeneration
11) Confidence 0.26 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927381 Disease Relevance 0.42 Pain Relevance 0
Female transgenic mice expressing the VPP rhodopsin mutation, known to cause a retinal degeneration, were bred to male transgenic mice expressing the fat-1 gene, which can convert n6 to n3 polyunsaturated fatty acids (PUFA).
Gene_expression (expressing) of rhodopsin in fat associated with targeted disruption and retinal degeneration
12) Confidence 0.26 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927381 Disease Relevance 0.56 Pain Relevance 0
To determine whether docosahexaenoic acid can protect against hereditary retinal degenerations in transgenic mice expressing the V20G, P23H, and P27L (VPP) rhodopsin mutations.


Gene_expression (expressing) of rhodopsin (P27L) associated with targeted disruption and retinal degeneration
13) Confidence 0.26 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927381 Disease Relevance 0.55 Pain Relevance 0
The percentage of rhodopsin positive M6a-overexpressing cells was not significantly, but few times higher than that of control cells (Figure 2B).
Gene_expression (overexpressing) of rhodopsin
14) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.15 Pain Relevance 0
Under these conditions, wildtype rhodopsin produces the inactive Meta I state.
Neg (inactive) Gene_expression (produces) of wildtype rhodopsin
15) Confidence 0.16 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.10
Also, a recent study demonstrated that ectopic expression of a microbial-type rhodopsin in retinal ganglion cells was capable of restoring visual function in mice lacking photoreceptors [52].
Gene_expression (expression) of rhodopsin in retinal ganglion cells associated with ganglion cysts
16) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 1.14 Pain Relevance 0.22
The transition from inactive Meta I to Meta II further involves uptake of a solute proton by a cytoplasmic group,14 which renders the conformational equilibrium between Meta I and Meta II pH-dependent.15 These two protonation switches are coupled during rhodopsin activation and this coupling was shown to be mediated by certain groups of the all-trans retinal ligand, such as the 9-methyl group on the polyene and the ionone ring.16
Gene_expression (activation) of rhodopsin
17) Confidence 0.14 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0.03
Most impressively, subretinal delivery of these nanoparticles transfected nearly all of the photoreceptor population and produced expression levels almost equal to that of rod opsin, the highest expressed gene in the retina.


Gene_expression (expressed) of rod opsin in photoreceptor
18) Confidence 0.14 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762345 Disease Relevance 0.07 Pain Relevance 0
As shown in this and in previous time-resolved UV-visible studies,36 the SB forms of E113Q mutants of rod rhodopsin do not produce transient photo-intermediates with a PSB on the main activation pathway.
Neg (not) Gene_expression (produce) of rod rhodopsin (E113Q)
19) Confidence 0.13 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
Another similarity between Cacna1fnob2 mice and CSNB2 patients is the depression of the OPs under scotopic conditions.
Gene_expression (depression) of OPs associated with depression
20) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0.35 Pain Relevance 0.12

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