INT200754

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 35
Total Number 38
Disease Relevance 6.30
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Rpe) carbohydrate metabolic process (Rpe)
Anatomy Link Frequency
retina 4
photoreceptors 3
sclera 3
choroid 3
INL 2
Rpe (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 19 88.36 High High
agonist 25 84.08 Quite High
Inflammatory stimuli 1 83.44 Quite High
Inflammation 126 81.64 Quite High
Dopamine 18 71.68 Quite High
cytokine 20 63.48 Quite High
alcohol 8 58.96 Quite High
chemokine 5 52.80 Quite High
Inflammatory mediators 3 42.88 Quite Low
Eae 12 42.76 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 94 100.00 Very High Very High Very High
Age-related Macular Degeneration 338 99.88 Very High Very High Very High
Fatigue 85 99.32 Very High Very High Very High
Myopia 249 96.68 Very High Very High Very High
Cytomegalovirus Infection 146 93.28 High High
Dislocations 3 92.84 High High
Respiratory Syncytial Virus 52 87.32 High High
Disease 123 86.44 High High
Diabetes Mellitus 144 86.04 High High
Ocular Toxicity (including Many Sub-types) 79 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, a preliminary study by Besharse et al. [23], also using PER2::LUC knockin mice, reported that the cornea, the iris, and RPE-choroid may also express circadian rhythms in luciferase activity and in Per2 mRNA.
Gene_expression (express) of RPE-choroid in choroid
1) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0.13 Pain Relevance 0.09
The eye cup containing the RPE-choroid was flattened using four small corner cuts, and then placed on the culture membrane (Millicell-CM, PICM030–50; Millipore, Billerica, MA) in a 35 mm Petri dish with 1.2 ml of 199 medium (02732; Cambrex, Walkersville, MD) containing 10 mm HEPES (pH 7.2), 0.1 mM D-Luciferin K salt (Molecular Imaging Products, Bend, OR), penicillin/streptomycin cocktail (2.5 ml ?
Gene_expression (containing) of RPE-choroid in choroid associated with imagery
2) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0.09 Pain Relevance 0.04
Circadian rhythms in Per2::LUC bioluminescence in cultured RPE and retina
Gene_expression (cultured) of RPE in retina
3) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
RPE scores after FT were used for statistical comparisons between conditions

Tracking performance

Gene_expression (scores) of RPE
4) Confidence 0.28 Published 2007 Journal Exp Brain Res Section Body Doc Link PMC1914220 Disease Relevance 0.41 Pain Relevance 0
As the RPE produces VEGF, such aberrant vessels usually proliferate and appear in some cases to form connections with the choroidal vascular system.
Gene_expression (produces) of RPE in RPE
5) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.24 Pain Relevance 0.03
The purity of RPE cells was evaluated by the expression of CRALBP (a marker for RPE cells and Müller cells) and RPE-65 (a marker for RPE cells) using specific antibodies.


Gene_expression (expression) of RPE
6) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
The expression of GPR109A in RPE was further confirmed with mouse primary RPE cells as rodents have only a single gene coding for the receptor.
Gene_expression (expression) of RPE
7) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.08 Pain Relevance 0
Greater than 95% of cells were positive for RPE-65 protein expression.
Gene_expression (expression) of RPE
8) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
However, as retinal Müller cells are also known to express CRALBP, the RPE cultures were analyzed also for expression of RPE-65, a RPE-specific marker (Figure 6D).
Spec (analyzed) Gene_expression (expression) of RPE
9) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
Prior to analyzing GPR109A expression in these cells, we evaluated the purity of the cells by morphology and by analyzing the expression of various RPE-specific cell markers (Figure 6).
Spec (analyzing) Gene_expression (expression) of RPE-specific
10) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
As RPE is a polarized cell with distinct apical and basolateral membranes, further studies were devoted to determining whether GPR109A expressed in the RPE cell layer distributes preferentially to one or both of these distinct membrane compartments.
Gene_expression (expressed) of RPE
11) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.34 Pain Relevance 0
Thus, our discovery that GPR109A is expressed in retina, particularly in the basolateral membrane of the RPE, has important physiologic and pathologic implications.



Gene_expression (expressed) of RPE in retina
12) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.24 Pain Relevance 0
The exclusive expression of GPR109A in RPE basolateral membrane, which has access to ?
Gene_expression (expression) of RPE
13) Confidence 0.14 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2642846 Disease Relevance 0.30 Pain Relevance 0
The purity of RPE cells was evaluated by the expression of CRALBP (a marker for RPE cells and Müller cells) and RPE-65 (a marker for RPE cells) using specific antibodies.


Gene_expression (expression) of RPE
14) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
However, as retinal Müller cells are also known to express CRALBP, the RPE cultures were analyzed also for expression of RPE-65, a RPE-specific marker (Figure 6D).
Spec (analyzed) Gene_expression (expression) of RPE-specific
15) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
The purity of RPE cells was evaluated by the expression of CRALBP (a marker for RPE cells and Müller cells) and RPE-65 (a marker for RPE cells) using specific antibodies.


Gene_expression (expression) of RPE
16) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
These results showing RPE-cell-specific expression of GPR109A mRNA were corroborated with data from immunofluorescence analysis of the receptor protein (Figure 5).
Gene_expression (expression) of RPE
17) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.08 Pain Relevance 0
Data obtained using intact mouse retinal sections were verified by examining GPR109A mRNA and protein expression in cultured RPE (ARPE-19), ganglion (RGC-5), and rMC-1 (Müller) cells.
Gene_expression (expression) of RPE in ganglion associated with ganglion cysts
18) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.21 Pain Relevance 0
Four weeks after subretinal injection, we observed intense eGFP expression in young and adult groups in the RPE, ONL, INL, OPL, IPL, RGC layers, and Müller cells (Figure 2B,C).
Gene_expression (groups) of RPE in INL
19) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.41 Pain Relevance 0
Consistent with recent publications from other investigators, we observed robust AAV-9 transduction in the outer retina (RPE and ONL), inner retina (Müller cells), and RGC layers [12,13].
Gene_expression (transduction) of RPE in retina
20) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 1.01 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox