INT200778

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 2.54
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
chondrocytes 2
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 501 98.96 Very High Very High Very High
licofelone 27 93.24 High High
Inflammation 163 88.48 High High
Pain 12 70.36 Quite High
COX-2 inhibitor 21 68.60 Quite High
cINOD 26 56.96 Quite High
cytokine 27 55.92 Quite High
Arthritis 18 48.28 Quite Low
Inflammatory mediators 9 45.20 Quite Low
Inflammatory response 19 42.56 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 538 98.96 Very High Very High Very High
INFLAMMATION 211 88.48 High High
Disease 30 87.04 High High
Myalgia 1 70.36 Quite High
Pain 11 53.60 Quite High
Arthritis 18 48.28 Quite Low
Stress 10 46.64 Quite Low
Muscle Disease 15 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Osteophyte 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HNE-induced 5-LOX and FLAP gene activation is differentially time dependent.
Positive_regulation (activation) of FLAP
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.16 Pain Relevance 0.08
HNE-induced LTB4 release through 5-LOX and FLAP upregulation
Positive_regulation (upregulation) of FLAP
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.20 Pain Relevance 0.10
Other studies, however, have demonstrated that the increase in LTB4 production was mainly related to upregulation of the FLAP gene [39] or to a combination of an increment in the activity and/or expression of 5-LOX [40,41].
Positive_regulation (upregulation) of FLAP
3) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03
The following 5 genes were significantly upregulated: ALOX5AP (+3.6-fold, p?
Positive_regulation (upregulated) of ALOX5AP
4) Confidence 0.43 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762369 Disease Relevance 0.07 Pain Relevance 0.07
Taken together, these results indicate that single treatment with HNE in OA chondrocytes induced the shunt from the production of PGE2 to LTB4 through COX-2 downregulation and 5-LOX and FLAP upregulation.


Positive_regulation (upregulation) of FLAP in chondrocytes associated with osteoarthritis
5) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.26 Pain Relevance 0.13
In addition to the involvement of PGE2 in HNE-induced 5-LOX and FLAP, we found data supporting the role of TGF-?
Positive_regulation (involvement) of FLAP
6) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.75 Pain Relevance 0.69
After 48 hours, when COX-2 expression decreased, the LTB4 level rose through 5-LOX and FLAP upregulation.
Positive_regulation (upregulation) of FLAP
7) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03
Our data indicated that 5-LOX and FLAP upregulation by HNE occurred, at least in part, at the transcription level, as determined by real-time quantitative RT-PCR and transient transfection experiments.
Positive_regulation (upregulation) of FLAP
8) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.17 Pain Relevance 0.11
The FLAP mRNA level was significantly enhanced after a short period (20 hours) of treatment with TGF-?
Positive_regulation (enhanced) of FLAP mRNA
9) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.13 Pain Relevance 0.06
This shunt was either related to an increase in 5-LO expression or that of FLAP through an IL-10-dependent or IL-18-dependent pathway in other cell systems.
Positive_regulation (increase) of FLAP
10) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.61 Pain Relevance 0.36
1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?
Neg (not) Positive_regulation (involved) of FLAP in chondrocytes
11) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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