INT200779

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.75
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
osteoblasts 4
chondrocytes 2
plasma 2
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 552 99.84 Very High Very High Very High
COX-2 inhibitor 18 98.36 Very High Very High Very High
antagonist 14 97.52 Very High Very High Very High
Inflammation 88 92.80 High High
Inflammatory response 10 67.28 Quite High
Inflammatory mediators 3 62.00 Quite High
Arthritis 6 54.80 Quite High
Pain 13 43.76 Quite Low
cINOD 38 39.60 Quite Low
metalloproteinase 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 568 99.84 Very High Very High Very High
INFLAMMATION 114 92.80 High High
Anaphylactic Hypersensitivity 1 86.56 High High
Hypersensitivity 1 85.76 High High
Asthma 2 81.84 Quite High
Toxicity 3 81.56 Quite High
Cancer 46 58.88 Quite High
Arthritis 6 54.80 Quite High
Pain 12 43.76 Quite Low
Pancreatic Cancer 34 33.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the nonspecific inhibitor of COX, naproxen, we abolished HNE-induced FLAP expression in OA chondrocytes after short or long periods of incubation.
Negative_regulation (abolished) of Gene_expression (expression) of FLAP in chondrocytes associated with osteoarthritis
1) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.28 Pain Relevance 0.14
Our analyses identified ALOX5AP gene expression in muscle had a high positive regression coefficients with plasma levels of phosphatidylethanolamine (42?
Negative_regulation (identified) of Gene_expression (expression) of ALOX5AP gene in plasma
2) Confidence 0.39 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762369 Disease Relevance 0.16 Pain Relevance 0.04
1 antibody reduced HNE-induced 5-LOX and FLAP expression by 40%, indicating the partial involvement of a TGF-?
Negative_regulation (reduced) of Gene_expression (expression) of FLAP
3) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0
M HNE to cultures lead to a switch to 5-LOX and FLAP mRNA expression, and consequently to LTB4 production.
Negative_regulation (switch) of Gene_expression (expression) of FLAP mRNA
4) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.25 Pain Relevance 0.13
In low OA osteoblasts, PGE2 treatments decreased FLAP expression about 2.5-fold (p < 0.025), whereas inhibiting endogenous PGE2 production with NS-398 did not inhibit FLAP expression.
Negative_regulation (inhibit) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
5) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.66 Pain Relevance 0.38
In low OA osteoblasts, PGE2 treatments decreased FLAP expression about 2.5-fold (p < 0.025), whereas inhibiting endogenous PGE2 production with NS-398 did not inhibit FLAP expression.
Negative_regulation (decreased) of Gene_expression (expression) of FLAP in osteoblasts associated with osteoarthritis
6) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.55 Pain Relevance 0.32
In addition, the expression of FLAP was variable in response to TGF-?
Negative_regulation (variable) of Gene_expression (expression) of FLAP
7) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.59 Pain Relevance 0.29
We measured the expression of the two key enzymes involved in LT production, 5-LO and FLAP (Figure 2).
Negative_regulation (measured) of Gene_expression (expression) of FLAP
8) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.66 Pain Relevance 0.33
expended by the pharmaceutical industry to produce inhibitors of FLAP, 5-LOX as
Negative_regulation (inhibitors) of Gene_expression (produce) of FLAP
9) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.53 Pain Relevance 0.16

General Comments

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