INT200790

Context Info Confidence 0.36 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0

signal transduction (Stat5a) nucleus (Stat5a) DNA binding (Stat5a) cytoplasm (Stat5a) signal transducer activity (Stat5a)

Anatomy Link Frequency spleens 2 Stat5a (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 3 28.24 cva 1 17.68 cytokine 3 5.00 Parenteral administration 2 5.00 anesthesia 1 5.00 isoflurane 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Myeloid Leukemia 9 62.08 Erythrocytosis 35 59.28 Myelofibrosis 18 58.00 Sprains And Strains 13 46.40 Anaemia 1 33.12 Fibrosis 3 28.24 Hyperplasia 1 19.72 Hemorrhage 10 17.68 Myelodysplastic Syndromes 62 15.92 Reticulocytosis 5 10.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.

Positive_regulation (increased) of Positive_regulation (activation) of Stat5 in spleens

1) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.24 Pain Relevance 0

General Comments

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