INT200792

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.69
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
platelet 7
leukocyte 1
Jak2 (Mus musculus)
Jak2 - V617F (4)
Pain Link Frequency Relevance Heat
fibrosis 12 86.88 High High
aspirin 16 84.44 Quite High
cva 6 10.80 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Parenteral administration 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 52 100.00 Very High Very High Very High
Erythrocytosis 142 99.88 Very High Very High Very High
Leukocytosis 24 99.04 Very High Very High Very High
Thrombosis Related Under Development 24 98.48 Very High Very High Very High
Hemorrhage 46 98.12 Very High Very High Very High
Disease 41 95.72 Very High Very High Very High
Myelodysplastic Syndromes 289 95.48 Very High Very High Very High
Myeloid Leukemia 36 94.12 High High
Splenomegaly 12 91.60 High High
Reticulocytosis 20 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the polycythemia, the effects of JAK2 V617F expression on leukocyte and platelet counts were more variable.
Regulation (effects) of Gene_expression (expression) of JAK2 V617F (V617F) in platelet associated with erythrocytosis
1) Confidence 0.61 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.05 Pain Relevance 0
Platelet counts were not affected in either strain despite expression of JAK2 V617F in megakaryocytes and markedly prolonged tail bleeding times.
Neg (not) Regulation (affected) of Gene_expression (expression) of JAK2 V617F (V617F) in Platelet associated with hemorrhage and sprains and strains
2) Confidence 0.61 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762384 Disease Relevance 1.64 Pain Relevance 0.04
JAK2 V617F expression did not affect the platelet count in either strain (Figure 2C), despite evidence of proviral expression of GFP in megakaryocytes (Figure 2D).
Neg (not) Regulation (affect) of Gene_expression (expression) of JAK2 V617F (V617F) in platelet associated with sprains and strains
3) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.39 Pain Relevance 0
Novel therapeutic options theoretically devoid of leukaemic risk, such as alpha-interferon and imatinib, affect JAK2 expression in some patients.
Regulation (affect) of Gene_expression (expression) of JAK2
4) Confidence 0.26 Published 2007 Journal Intern Emerg Med Section Abstract Doc Link PMC2780604 Disease Relevance 0.55 Pain Relevance 0.04
In contrast to the polycythemia, the effects of JAK2 V617F expression on leukocyte and platelet counts were more variable.
Regulation (effects) of in leukocyte Gene_expression (expression) of JAK2 V617F (V617F) in platelet associated with erythrocytosis
5) Confidence 0.21 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.05 Pain Relevance 0

General Comments

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