INT200797

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.19
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 1
Ptprv (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 19 95.84 Very High Very High Very High
cINOD 14 79.00 Quite High
cytokine 27 75.44 Quite High
antagonist 1 73.60 Quite High
Inflammation 56 61.44 Quite High
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 85 99.24 Very High Very High Very High
Myelodysplastic Syndromes 62 97.36 Very High Very High Very High
Congenital Anomalies 10 92.16 High High
Acantholysis 65 87.60 High High
Bullous Skin Disease 304 86.60 High High
Hypersensitivity 1 85.00 Quite High
Myelofibrosis 18 74.76 Quite High
Leukemia 3 71.96 Quite High
Thrombosis Related Under Development 5 69.56 Quite High
Hemorrhage 10 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abnormally increased tyrosine phosphatase activity has also been characterized in erythroid progenitors in PV [10].
Positive_regulation (increased) of tyrosine phosphatase associated with myelodysplastic syndromes
1) Confidence 0.14 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.60 Pain Relevance 0.04
To explore the possibility of immunomodulating CD40 activity, we showed that CD45, a protein tyrosine phosphatase (PTP), activation inhibits CD40L-induced microglial activation via down-regulation of the p44/42 mitogen activated protein kinase (MAPK) pathway [14].
Positive_regulation (activation) of tyrosine phosphatase
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.59 Pain Relevance 0.32
CD45, a protein-tyrosine phosphatase that is constitutively expressed on microglia [25], is markedly increased on microglia from AD frontal cortices [24], [32].
Positive_regulation (increased) of tyrosine phosphatase in microglia associated with disease
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.10 Pain Relevance 0
7 nAChR reduced p120catenin phosphorylation both on the level of Src activation as well as by activation of the tyrosine phosphatase.
Positive_regulation (activation) of tyrosine phosphatase
4) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.89 Pain Relevance 0.23

General Comments

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