INT200799

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat5a) nucleus (Stat5a) DNA binding (Stat5a)
cytoplasm (Stat5a) signal transducer activity (Stat5a)
Anatomy Link Frequency
spleens 4
Stat5a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 6 22.40 Low Low
cva 2 17.68 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Parenteral administration 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 18 56.24 Quite High
Erythrocytosis 70 53.44 Quite High
Myelofibrosis 36 52.16 Quite High
Sprains And Strains 26 40.56 Quite Low
Anaemia 2 27.28 Quite Low
Fibrosis 6 22.40 Low Low
Hyperplasia 2 19.72 Low Low
Hemorrhage 20 17.68 Low Low
Myelodysplastic Syndromes 124 10.08 Low Low
Splenomegaly 6 8.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Positive_regulation (activation) of Gene_expression (expression) of Stat5 in spleens
1) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.21 Pain Relevance 0
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Positive_regulation (activation) of Gene_expression (expression) of Stat5 in spleens
2) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.16 Pain Relevance 0

General Comments

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