INT20080

Context Info Confidence 0.03 First Reported 1985 Last Reported 1990 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.42 Pain Relevance 1.12

extracellular region (PRLR) plasma membrane (PRLR)

PRLR (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 1 98.68 agonist 2 96.84 opiate 7 89.44 Opioid 4 87.76 Morphine 2 86.80 antagonist 1 65.20 Dopamine 1 40.32

Disease Link Frequency Relevance Heat Cancer 2 99.96 Prolactinoma 3 85.68 Galactorrhea 2 72.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This acute release of PRL was positively correlated (r = 0.06074; P less than 0.001) with a significant increase in secretion of the hPRL species (P less than 0.05).

Localization (secretion) of hPRL

1) Confidence 0.03 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2118537 Disease Relevance 0.07 Pain Relevance 0.27

Subsequently EKC was added to hPRL-secreting tumor cells in primary culture, alone or in combination with the dopaminergic agonist bromocriptine, and PRL release was measured.

Localization (secreting) of hPRL-secreting associated with cancer and agonist

2) Confidence 0.01 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2995431 Disease Relevance 0.35 Pain Relevance 0.85

General Comments

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