INT200807

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.46
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jak2, Mvd) kinase activity (Jak2, Mvd) cell differentiation (Jak2)
lyase activity (Mvd) histone binding (Jak2) peroxisome (Mvd)
Anatomy Link Frequency
spleen 1
Jak2 (Mus musculus)
Mvd (Mus musculus)
Jak2 - V617F (4)
Pain Link Frequency Relevance Heat
cva 4 58.96 Quite High
anesthesia 4 40.88 Quite Low
isoflurane 4 40.44 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Parenteral administration 8 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythrocytosis 140 99.88 Very High Very High Very High
Sprains And Strains 52 99.08 Very High Very High Very High
Myelodysplastic Syndromes 248 98.56 Very High Very High Very High
Congenital Anomalies 40 95.56 Very High Very High Very High
Myeloid Leukemia 36 91.68 High High
Thrombosis Related Under Development 20 90.96 High High
Hemorrhage 40 89.16 High High
Lifespan 12 82.40 Quite High
Splenomegaly 12 77.60 Quite High
Leukocytosis 24 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of proviral clones in BM and spleen cells from mice with JAK2 V617F-induced MPD was determined by digesting genomic DNA with BglII, fractionation on agarose gels, transfer to nylon membranes, and hybridization with a radiolabeled probe from the GFP gene, as described [21].


JAK2 V617F (V617F) Positive_regulation (induced) of MPD in spleen
1) Confidence 0.18 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.16 Pain Relevance 0
To investigate the molecular pathogenesis of MPD induced by JAK2 V617F, we expressed murine JAK2 WT or JAK2 V617F in BM of two different strains of mice, Balb/c and C57Bl/6 (B6), using retroviral transduction and transplantation [21].
JAK2 V617F (V617F) Positive_regulation (induced) of MPD associated with sprains and strains
2) Confidence 0.18 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.40 Pain Relevance 0
Pathological characterization of MPD induced by JAK2 V617F
JAK2 V617F (V617F) Positive_regulation (induced) of MPD
3) Confidence 0.18 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.50 Pain Relevance 0.03
Despite the marked polycythemia, the MPD induced by JAK2 V617F was non-fatal in both strains, with recipients surviving for many months.
JAK2 V617F (V617F) Positive_regulation (induced) of MPD associated with erythrocytosis and sprains and strains
4) Confidence 0.18 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.39 Pain Relevance 0.03

General Comments

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