INT200808

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Akt1, Insrr) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Akt1 (Mus musculus)
Insrr (Mus musculus)
Akt1 - V617F (1) Insrr - V617F (1)
Pain Link Frequency Relevance Heat
gABA 129 92.72 High High
tetrodotoxin 9 80.16 Quite High
cytokine 3 53.92 Quite High
Dopamine 75 50.00 Quite Low
GABAergic 13 42.48 Quite Low
Parenteral administration 2 17.56 Low Low
antagonist 28 5.00 Very Low Very Low Very Low
agonist 28 5.00 Very Low Very Low Very Low
Neurotransmitter 23 5.00 Very Low Very Low Very Low
Glutamate 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 62 99.08 Very High Very High Very High
Erythrocytosis 35 97.76 Very High Very High Very High
Leukocytosis 6 63.36 Quite High
Syndrome 1 63.12 Quite High
Sprains And Strains 13 50.00 Quite Low
Myelofibrosis 18 32.12 Quite Low
Thrombosis Related Under Development 5 12.40 Low Low
Ganglion Cysts 26 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Hemorrhage 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of JAK2 V617F in patients with homozygous mutations may increase severity of the phenotype in PV [41], perhaps because the mutant and WT JAK2 kinases compete for Epo receptor binding [13].
kinases (V617F) Binding (binding) of receptor (V617F) associated with myelodysplastic syndromes
1) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.98 Pain Relevance 0.03
In addition, casein kinases associate with GABAA and GABAC receptor subunits [58,59].
kinases Binding (associate) of receptor
2) Confidence 0.00 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.59

General Comments

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