INT200818

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Akt1, Lyn) cytoplasm (Akt1, Lyn) signal transduction (Akt1, Lyn)
nucleus (Akt1, Lyn) plasma membrane (Akt1, Lyn) kinase activity (Akt1, Lyn)
Akt1 (Mus musculus)
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 1 43.44 Quite Low
fibrosis 3 26.64 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 62 96.56 Very High Very High Very High
Reticulocytosis 5 94.00 High High
Erythrocytosis 35 93.20 High High
Myeloid Leukemia 9 64.96 Quite High
Disease 9 62.92 Quite High
Myelofibrosis 18 56.04 Quite High
Hematological Disease 4 46.40 Quite Low
Fibrosis 3 26.64 Quite Low
Sprains And Strains 13 23.52 Low Low
Congenital Anomalies 10 16.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest that other Src family kinases are not compensating for deficiency of Lyn, Hck, and Fgr, and argue that therapy directed at Src kinases will be ineffective in PV patients.
kinases Neg (not) Positive_regulation (compensating) of Negative_regulation (deficiency) of Lyn associated with myelodysplastic syndromes
1) Confidence 0.25 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.02 Pain Relevance 0

General Comments

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