INT200819

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) histone binding (Jak2) cytoplasm (Jak2)
cytosol (Jak2) extracellular space (Epo) signal transduction (Jak2)
Anatomy Link Frequency
erythrocytes 2
Epo (Mus musculus)
Jak2 (Mus musculus)
Jak2 - V617F (1)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythrocytosis 35 100.00 Very High Very High Very High
Myelodysplastic Syndromes 62 92.56 High High
Sprains And Strains 13 82.24 Quite High
Leukocytosis 6 80.88 Quite High
Thrombosis Related Under Development 5 79.12 Quite High
Lifespan 3 60.32 Quite High
Myeloid Leukemia 9 40.88 Quite Low
Hemorrhage 10 7.20 Low Low
Myelofibrosis 18 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results indicate that JAK2 V617F expression directly induces polycythemia in mice through Epo-independent overproduction of erythrocytes.
Epo Positive_regulation (induces) of Gene_expression (expression) of JAK2 V617F (V617F) in erythrocytes associated with erythrocytosis
1) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.91 Pain Relevance 0

General Comments

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