INT200835

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 15
Disease Relevance 9.02
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd59a)
Anatomy Link Frequency
body 3
neuronal 2
brain 2
testis 1
Cd59a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 332 99.92 Very High Very High Very High
Inflammatory response 37 95.44 Very High Very High Very High
Inflammation 113 89.68 High High
cytokine 33 81.00 Quite High
chemokine 11 59.12 Quite High
isoflurane 22 5.00 Very Low Very Low Very Low
cva 16 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Hippocampus 11 5.00 Very Low Very Low Very Low
tissue acidosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 143 99.92 Very High Very High Very High
Targeted Disruption 167 99.68 Very High Very High Very High
Middle Cerebral Artery Infarction 462 99.52 Very High Very High Very High
Disease 41 99.32 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 65 98.96 Very High Very High Very High
Brain Injury 55 97.68 Very High Very High Very High
Injury 63 97.56 Very High Very High Very High
INFLAMMATION 150 95.44 Very High Very High Very High
Cv Unclassified Under Development 121 92.60 High High
Stroke 237 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, because of low levels of neuronal CD59a expression, the neuronal capacity of controlling activation of complement is limited.
Gene_expression (expression) of CD59a in neuronal
1) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.62 Pain Relevance 0.09
CD59a is constitutively expressed in neurons, most probably to protect from so-called autologous "innocent bystander" cell lysis after complement system activation in brain injury [21,22].
Gene_expression (expressed) of CD59a in brain associated with brain injury
2) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.52 Pain Relevance 0.10
Thus, we alternatively speculate that the longer occlusion interval in the 60 min MCAO model may dampen local CD59a-expression, so that the remaining CD59a expression in the wild-type mice (CD59a+/+) is of minor relevance when compared to the complete lack of CD59a expression in the knockout mice.
Gene_expression (expression) of CD59a associated with targeted disruption and middle cerebral artery infarction
3) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.98 Pain Relevance 0.15
Moreover, formation of MAC was shown to trigger endothelial damage, cytotoxicity, and neurodegneration in vivo [16,17] and deficient expression of CD59 in a rare human disease (Paroxysmal nocturnal haemoglobinuria) is associated with an increased risk of thrombotic events [18,19].
Gene_expression (expression) of CD59 associated with paroxysmal nocturnal hemoglobinuria and disease
4) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.48 Pain Relevance 0.08
CD59 is anchored to the cell membrane via glycosyl phosphatidyl inositol (GPI), and expressed ubiquitously on cells which are in contact with body fluids containing components of the complement system including cells in the CNS.
Gene_expression (expressed) of CD59 in body
5) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.66 Pain Relevance 0.13
Thus, we alternatively speculate that the longer occlusion interval in the 60 min MCAO model may dampen local CD59a-expression, so that the remaining CD59a expression in the wild-type mice (CD59a+/+) is of minor relevance when compared to the complete lack of CD59a expression in the knockout mice.
Gene_expression (expression) of CD59a associated with targeted disruption and middle cerebral artery infarction
6) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 1.04 Pain Relevance 0.15
Previous in vitro experiments, as well as immunostaining of human brains suggested that oligodendrocytes can also express low levels of CD59a [21].
Gene_expression (express) of CD59a in brains
7) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.82 Pain Relevance 0.11
Further, CD59 was shown to efficiently protect human NT2-N neuronal cells against complement-mediated cell injury [41,42].
Gene_expression (protect) of CD59 in neuronal associated with injury
8) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.78 Pain Relevance 0.14
Thus, we alternatively speculate that the longer occlusion interval in the 60 min MCAO model may dampen local CD59a-expression, so that the remaining CD59a expression in the wild-type mice (CD59a+/+) is of minor relevance when compared to the complete lack of CD59a expression in the knockout mice.
Gene_expression (expression) of CD59a-expression associated with targeted disruption and middle cerebral artery infarction
9) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 1.10 Pain Relevance 0.16
C3a, C5a), and which were not affected by CD59a expression.
Gene_expression (expression) of CD59a
10) Confidence 0.60 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.64 Pain Relevance 0.28
CD59a has been characterized as the primary regulator of MAC assembly in the mouse, since the expression of the second CD59 isoform in mice, CD59b, was found to be restricted to testis [39].
Gene_expression (expression) of CD59 in testis
11) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.90 Pain Relevance 0.26
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Neg (not) Gene_expression (immunoreactive) of CD59
12) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.24 Pain Relevance 0
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Neg (not) Gene_expression (immunoreactive) of CD59
13) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.25 Pain Relevance 0
CD59 prevents formation of the C5b-9 complex (MAC) on cell surfaces and is highly expressed on cell membranes throughout the body.


Gene_expression (expressed) of CD59 in body
14) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
CD59 prevents formation of the C5b-9 complex (MAC) on cell surfaces and is highly expressed on cell membranes throughout the body.


Gene_expression (expressed) of CD59 in body
15) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0

General Comments

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