INT200838

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.73
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Isl1) intracellular (Isl1) DNA binding (Isl1)
Anatomy Link Frequency
vasculature 1
amygdala 1
hippocampus 1
Isl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 84 99.72 Very High Very High Very High
amygdala 80 99.40 Very High Very High Very High
gABA 6 86.88 High High
imagery 27 80.24 Quite High
Pain 4 80.20 Quite High
Neuropeptide 2 79.56 Quite High
substance P 4 78.84 Quite High
anesthesia 3 55.20 Quite High
tolerance 1 52.72 Quite High
Spinal cord 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 10 85.52 High High
Pain 4 80.20 Quite High
Neurodegenerative Disease 4 72.48 Quite High
Nervous System Malformation 4 71.20 Quite High
Sprains And Strains 152 50.00 Quite Low
Diabetes Mellitus 27 50.00 Quite Low
Viral Infection 2 41.04 Quite Low
Immunization 1 37.76 Quite Low
Hemorrhage 1 27.68 Quite Low
Targeted Disruption 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While it is formally possible that all of the tabulated SSTFs are regulated in all green cells, it is known that Foxd3 and Isl1 are upregulated, and Pax2 and Lmx1b are downregulated, in different populations [9].
Positive_regulation (upregulated) of Isl1
1) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
For example, we observed an enrichment of genes involved in transcriptional processes that distinguished between the amygdala and hippocampus; these genes included Isl1, Fhl2, Tnfrsf25 and Zcchc12.
Positive_regulation (included) of Isl1 in hippocampus associated with hippocampus and amygdala
2) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.37 Pain Relevance 0.52
In Lbx1 mutants, Foxd3 is specifically upregulated in the dI4LA and I4 populations, and Isl1 is specifically upregulated in the I4LB and I5 populations, respectively The upregulation of each of these genes in only half of the green cells resulted in some of the strongest effects observed.
Positive_regulation (upregulated) of Isl1
3) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
For example, we observed an enrichment of genes involved in transcriptional processes that distinguished between the amygdala and hippocampus; these genes included Isl1, Fhl2, Tnfrsf25 and Zcchc12.
Positive_regulation (included) of Isl1 in amygdala associated with hippocampus and amygdala
4) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.37 Pain Relevance 0.52
Consistent with the global gene expression analysis, many genes known to be induced in early ectodermal differentiation of ESCs such as Isl1, Neurog3, Pax6 and Pcsk1 were not upregulated (fig. 2i).
Neg (not) Positive_regulation (upregulated) of Isl1
5) Confidence 0.13 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
This intravital approach has the notable advantage of allowing for detailed visualization of pancreatic islet vasculature, as is achieved by intravenous injection of fluorescently labeled agents (Figure 1D; Movie S2).
Positive_regulation (pancreatic) of islet in vasculature
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009738 Disease Relevance 0 Pain Relevance 0.15

General Comments

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