INT200842

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) RNA binding (Atxn1) nucleus (Atxn1)
cytoplasm (Atxn1)
Atxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 63.36 Quite High
Calcium channel 5 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 85.00 Quite High
Ataxia 33 76.20 Quite High
Cancer 5 64.96 Quite High
Overdose 1 62.80 Quite High
Disease 29 60.92 Quite High
Teratoma 10 60.36 Quite High
Severe Combined Immunodeficiency 2 50.00 Quite Low
Repression 1 49.68 Quite Low
Spinocerebellar Ataxia Type 2 17 28.44 Quite Low
Retina Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of HSJ2 in these cells reduces aggregation of ataxin-1, suggesting a possible therapeutic strategy.
Negative_regulation (reduces) of ataxin-1 Binding (aggregation) of
1) Confidence 0.35 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.41 Pain Relevance 0
The cells were then trypsinized for 1 minute, centrifuged, washed with PBS, fixed in 4% paraformaldehyde for 0.5 hour at room temperature, washed and blocked in 2%FCS for 0.5 hour at room temperature with agitation. 1.5×105cells were then incubated with each of the following conjugated monoclonal antibodies: Tie-2, Flk-1, CD34, c-Kit, Thy-1, Sca-1 (PharMingen, San Diego, CA) for 90 mins at room temperature.
Negative_regulation (blocked) of Sca-1 Binding (temperature) of
2) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.30 Pain Relevance 0.06

General Comments

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