INT200851

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.77
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Anatomy Link Frequency
lung 2
bars 1
epithelial cell 1
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 99.82 Very High Very High Very High
Inflammatory response 6 98.20 Very High Very High Very High
imagery 134 75.00 Quite High
Kinase C 2 67.76 Quite High
backache 2 25.00 Low Low
antagonist 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 171 100.00 Very High Very High Very High
INFLAMMATION 29 99.82 Very High Very High Very High
Chlamydia Infection 38 98.96 Very High Very High Very High
Adenocarcinoma 198 97.16 Very High Very High Very High
Pancreatic Cancer 42 96.72 Very High Very High Very High
Disease Progression 4 96.20 Very High Very High Very High
Viral Infection 24 95.32 Very High Very High Very High
Immunization 15 93.96 High High
Cancer 107 92.52 High High
Asthma 3 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peptide in clone 27, the researchers report, binds to plectin-1, a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells.
plectin-1 Binding (binds) of associated with adenocarcinoma
1) Confidence 0.44 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2292750 Disease Relevance 1.03 Pain Relevance 0.16
Notable in this regard, recent publications illustrate that plectin-1 can be recruited to the membrane during epithelial cell transformation [32].
plectin-1 Binding (recruited) of in epithelial cell
2) Confidence 0.33 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.70 Pain Relevance 0.03
Given that antibodies are extraordinarily powerful at neutralizing virus, preventing further infection, clearing antigen and even dampening inflammation via FcR ligation, the accelerated IgG and IgA responses in the lung most likely contribute, at least partially, to the enhanced viral clearance in PCN-treated mice.
PCN-treated Binding (ligation) of in lung associated with inflammation and infection
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.85 Pain Relevance 0.12
In fact, our results suggest that the PCN-treatment prior to infection is associated with an amelioration of the often excessive inflammatory responses that are seen during the resolution of pulmonary viral infections [16] as well as airway hyperresponsiveness and inflammation associated with asthma.
PCN Binding (associated) of associated with asthma, inflammatory response, inflammation, viral infection and infection
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 1.01 Pain Relevance 0.14
The lack of any lung damage associated with the PCN treatment was further supported by the absence of any increase in the levels of serum albumin (Figure 3C) and lactate dehydrogenase (Figure 3D) recovered in the BALF of these mice at this time and the absence of any weight loss during the PCN treatment regimen (data not shown).
PCN Binding (associated) of in lung associated with weight loss
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.54 Pain Relevance 0
On day 12, EBs treated with dorsomorphin or DMSO were dissociated, and stained with anti-?
EBs Binding (stained) of
6) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0 Pain Relevance 0
To test if putative RoSH cells in adherent monolayer culture generated by plating 5 day EBs could be isolated using CD9 and SSEA-1 as selectable markers, the heterogenous differentiating EB culture was sorted for CD9hi, SSEA1?
EBs Binding (plating) of
7) Confidence 0.03 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
However, these CTH1/CAF01 specific antibodies only had minimal ability to bind MoPn EBs (Fig. 7B, black bars) or Ct serovar D (results not shown).
EBs Binding (bind) of in bars associated with chlamydia infection
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.63 Pain Relevance 0

General Comments

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