INT200874

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 5.69
Pain Relevance 7.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
bars 4
nucleus 4
SH-SY5Y 2
sciatic nerve 2
neurons 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 293 100.00 Very High Very High Very High
lidocaine 102 100.00 Very High Very High Very High
mu opioid receptor 78 100.00 Very High Very High Very High
Sciatic nerve 31 100.00 Very High Very High Very High
long-term potentiation 8 100.00 Very High Very High Very High
cytokine 122 99.84 Very High Very High Very High
TRP channel 3 99.76 Very High Very High Very High
Nicotine 14 99.58 Very High Very High Very High
Dopamine 227 99.56 Very High Very High Very High
agonist 231 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 49 100.00 Very High Very High Very High
Immunization 40 99.98 Very High Very High Very High
Stress Incontinence 35 99.76 Very High Very High Very High
Mevalonate Kinase Deficiency 58 97.96 Very High Very High Very High
Depression 38 94.60 High High
Infection 144 94.56 High High
INFLAMMATION 185 90.24 High High
Chlamydia Infection 83 89.44 High High
Multiple Sclerosis 53 87.72 High High
Endotoxemia 14 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In neurons, which displayed an inhibitory response to 5-HT there was a rapid hyperpolarization (Fig. 1A) from a mean membrane potential of ?
Positive_regulation (was) of Localization (hyperpolarization) of Fig in neurons
1) Confidence 0.38 Published 2009 Journal Neuroscience Section Body Doc Link PMC2661429 Disease Relevance 0 Pain Relevance 0.12
This heat-induced ATP release was significantly reduced by ruthenium red (RR, 50 µM), a broad TRP channel inhibitor (Fig. 6, red) at higher temperature range: in the presence of ruthenium red, the RR-insensitive ATP release activated at lower temperature range (>?
Positive_regulation (activated) of Localization (release) of Fig associated with trp channel
2) Confidence 0.28 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0.19 Pain Relevance 0.14
Four hours after zymosan challenge, both S100A8 and S100A9 were significantly increased in the presence of lidocaine (Fig. 4A and Table 1).
Positive_regulation (increased) of Localization (lidocaine) of Fig associated with lidocaine
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.37 Pain Relevance 0.70
Moreover, both secretion of NSE (Fig. 6D, left panel) and CgA accumulation (Fig. 6D, right panel and Figure S1) were markedly diminished while Akt phosphorylation was unchanged hence suggesting that SphK1 inhibition can to a certain extent block the NE transdifferentiation.
Positive_regulation (accumulation) of Localization (secretion) of Fig
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
Increases in IL-12p70 were balanced by similar increases in IL-10 secretion (Fig. 3b).
Positive_regulation (increases) of Localization (secretion) of Fig
5) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.11 Pain Relevance 0.29
B p65 into the nucleus in a time-dependent manner, and PZ pretreatment 6 h before LPS significantly inhibited the nuclear translocation at 24 h after LPS addition (Fig. 8).


Positive_regulation (after) of Localization (translocation) of Fig in nucleus
6) Confidence 0.19 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.36 Pain Relevance 0.09
In contrast, methanandamide induced a low to moderate internalization of the CB1R (Fig. 3B).
Positive_regulation (induced) of Localization (internalization) of Fig
7) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.59
On the other hand, reduced RGSZ2 expression caused increased Gz signaling and rapid desensitization of MORs [47], which lasted for more than 2 weeks (Fig. 5E).
Positive_regulation (increased) of Localization (desensitization) of Fig associated with mu opioid receptor
8) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.41
On the other hand, reduced RGSZ2 expression caused increased Gz signaling and rapid desensitization of MORs [47], which lasted for more than 2 weeks (Fig. 5E).
Positive_regulation (caused) of Localization (desensitization) of Fig associated with mu opioid receptor
9) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.42
Even at concentrations up to 10 µM, catechin or ethyl gallate did not affect LPS-induced HMGB1 release (Fig. 4B), indicating that functional groups of both catechin and gallate are needed for EGCG's HMGB1-inhibiting properties.


Positive_regulation (induced) of Localization (release) of Fig
10) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.16 Pain Relevance 0.03
-hexosaminidase release (Fig. 3 B), and similar activation-dependent secretion of cytokines TNF?
Positive_regulation (dependent) of Localization (secretion) of Fig associated with cytokine
11) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.05
-hexosaminidase release (Fig. 3 B), and similar activation-dependent secretion of cytokines TNF?
Positive_regulation (activation) of Localization (secretion) of Fig associated with cytokine
12) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.05
We found that CTH1/CAF01 immunization induced very high levels of CTH1-specific IgG1 and IgG2a in the vaginal secretions (Fig. 7A, black bars).
Positive_regulation (induced) of Localization (secretions) of Fig in bars associated with immunization
13) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.64 Pain Relevance 0
We found that CTH1/CAF01 immunization induced very high levels of CTH1-specific IgG1 and IgG2a in the vaginal secretions (Fig. 7A, black bars).
Positive_regulation (levels) of Localization (secretions) of Fig in bars associated with immunization
14) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.64 Pain Relevance 0
Nuclear translocation (Fig. 5D) of Smad was decreased with myostatin inhibition and increased with myostatin overexpression.
Positive_regulation (increased) of Localization (translocation) of Fig
15) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.06 Pain Relevance 0
We investigated microglial MT-MMP expression at peak disease (Fig. 2).
Spec (investigated) Positive_regulation (microglial) of Localization (disease) of Fig associated with disease
16) Confidence 0.14 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 1.04 Pain Relevance 0.21
GSI alone was associated with a very low NICD level, as expected, but dendritic trees showed no recovery (Fig. 9), which argues that GSI inhibited both ?
Positive_regulation (argues) of Neg (no) Localization (recovery) of Fig in dendritic trees associated with stress incontinence
17) Confidence 0.13 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.46 Pain Relevance 0
B binding activity (Fig. 2B) and increased nuclear accumulation of Nrf2 (Fig. 2C), which correspond with GSH levels being depleted to below 20% of the basal level (Fig. 2A); a BSO-mediated increase in Nrf2 has been seen previously in our lab [18].
Positive_regulation (increased) of Localization (accumulation) of Fig
18) Confidence 0.11 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.12 Pain Relevance 0
B binding activity (Fig. 2B) and increased nuclear accumulation of Nrf2 (Fig. 2C), which correspond with GSH levels being depleted to below 20% of the basal level (Fig. 2A); a BSO-mediated increase in Nrf2 has been seen previously in our lab [18].
Positive_regulation (increased) of Localization (accumulation) of Fig
19) Confidence 0.11 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.13 Pain Relevance 0
B binding activity (Fig. 2B) and increased nuclear accumulation of Nrf2 (Fig. 2C), which correspond with GSH levels being depleted to below 20% of the basal level (Fig. 2A); a BSO-mediated increase in Nrf2 has been seen previously in our lab [18].
Positive_regulation (increased) of Localization (accumulation) of Fig
20) Confidence 0.11 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.13 Pain Relevance 0

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