INT200893

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
hypothalamus 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 113 99.30 Very High Very High Very High
depression 28 88.76 High High
Hippocampus 78 84.00 Quite High
nMDA receptor 147 82.16 Quite High
cerebral cortex 12 56.48 Quite High
antagonist 25 23.44 Low Low
Glutamate 25 12.84 Low Low
long-term potentiation 30 5.00 Very Low Very Low Very Low
agonist 19 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 114 95.24 Very High Very High Very High
Depression 28 88.76 High High
Sprains And Strains 7 69.44 Quite High
Targeted Disruption 3 36.56 Quite Low
Urological Neuroanatomy 15 27.52 Quite Low
Stroke 1 20.68 Low Low
Drug Induced Neurotoxicity 3 19.48 Low Low
Cognitive Disorder 27 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, when we examined the amount of synaptosomal GluR1 expression 10 minutes following treatment with strong NMDA and co-application of weak NMDA and dopamine groups, we observed a significant reduction in the amount of GluR1 in synaptosomes (1±0.07, n?
Negative_regulation (reduction) of Transcription (amount) of GluR1 associated with dopamine
1) Confidence 0.08 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.23 Pain Relevance 0.38
The mRNA expression for the GluN1 subunit is also decreased in the hypothalamus of middle-aged female Sprague-Dawley rats and C57BL/6 mice, which may play a role in reproductive senescence (Zuo et al., 1996; Adjan et al., 2008).
Negative_regulation (decreased) of Transcription (expression) of GluN1 in hypothalamus associated with aging
2) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.37 Pain Relevance 0.20

General Comments

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