INT200895

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.08
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
nucleus 2
brain 1
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 226 99.84 Very High Very High Very High
Central nervous system 24 97.96 Very High Very High Very High
Pain 208 97.44 Very High Very High Very High
Spinal cord 105 92.84 High High
Lasting pain 51 92.76 High High
Hippocampus 93 82.44 Quite High
medulla 9 81.52 Quite High
addiction 2 80.32 Quite High
Thalamus 3 76.08 Quite High
cerebral cortex 3 73.92 Quite High
Disease Link Frequency Relevance Heat
Pain 274 97.44 Very High Very High Very High
Apoptosis 2 94.20 High High
Carcinoma 2 93.28 High High
Nociception 86 87.76 High High
Targeted Disruption 2 85.48 High High
Urological Neuroanatomy 5 84.96 Quite High
Hypersensitivity 8 68.60 Quite High
Hyperalgesia 55 63.00 Quite High
Depression 41 50.00 Quite Low
Cognitive Disorder 19 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spite of this global diffusion, regional differences in the relative abundance of ERK1 and ERK2 have also been described by previous reports [45,47].
Localization (abundance) of ERK2
1) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.31 Pain Relevance 0.77
Under normal state, the relative abundance of constitutive ERK1 and ERK2 differs greatly among specific regions in the rat CNS, while under pain state, both ERK1 and ERK2 can be effectively phosphorylated with a long-term duration by both transient and persistent pain, but with their response patterns being different from each other across distinct regions as well.
Localization (abundance) of ERK2 associated with pain, lasting pain and central nervous system
2) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.70 Pain Relevance 0.65
ERK2 activation kinetics under co-application of dopamine and NMDA
Localization (application) of ERK2 associated with dopamine
3) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.22
The various MAPKs, especially ERK2 and p38 are known to be activated by ACs, and in rare cases (though sometimes reciprocal) even JNK.
Localization (reciprocal) of ERK2
4) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.09 Pain Relevance 0.08
Oritz and his colleagues found that, while ERK immunoreactivity was widely distributed in the rat brain, the relative abundance of ERK1 and ERK2 differed by close to 10-fold among the regions studied.
Localization (abundance) of ERK2 in brain
5) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.76
Proliferation of fibroblast and differentiation of PC12 cells was proven to depend on localized signalling i.e. the translocation of Erk1/2 to the nucleus [55,56].
Localization (localized) of Erk1/2 in nucleus
6) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.35 Pain Relevance 0.17
Proliferation of fibroblast and differentiation of PC12 cells was proven to depend on localized signalling i.e. the translocation of Erk1/2 to the nucleus [55,56].
Localization (translocation) of Erk1/2 in nucleus
7) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.34 Pain Relevance 0.16

General Comments

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