INT20093

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.38
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Akr1b1) oxidoreductase activity (Akr1b1) nucleolus (Akr1b1)
nucleus (Akr1b1) cytoplasm (Akr1b1)
Akr1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 2 99.46 Very High Very High Very High
cINOD 2 99.40 Very High Very High Very High
Pain 3 72.92 Quite High
anesthesia 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 2 99.46 Very High Very High Very High
INFLAMMATION 2 99.28 Very High Very High Very High
Neuropathic Pain 1 54.32 Quite High
Diabetes Mellitus 1 53.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that some sustained improvement in symptomatic diabetic neuropathy may be obtained following aldose-reductase inhibition with tolrestat 200 mg once daily.
aldose-reductase Neg (inhibition) Binding (inhibition) of associated with diabetic neuropathy
1) Confidence 0.36 Published 1990 Journal Diabetologia Section Abstract Doc Link 2119323 Disease Relevance 0.28 Pain Relevance 0.23
This mutation also dramatically decreased the catalytic efficiency observed with one-, two-, and three-ring substrates and decreased the binding affinity for nonsteroidal anti-inflammatory drugs but had little effect on the binding of aldose reductase inhibitors.
aldose reductase Binding (binding) of associated with inflammation and cinod
2) Confidence 0.31 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8939970 Disease Relevance 0.10 Pain Relevance 0.10
Genes commonly regulated included those associated with cell defense (heat shock protein 10, aldose reductase, Bcl-xS).
aldose reductase Binding (associated) of
3) Confidence 0.17 Published 2004 Journal Anesthesiology Section Body Doc Link 15108959 Disease Relevance 0 Pain Relevance 0

General Comments

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