INT200942

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FDFT1) oxidoreductase activity (FDFT1) endoplasmic reticulum (FDFT1)
transferase activity, transferring alkyl or aryl (other than methyl) groups (FDFT1)
FDFT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cannabis 32 87.88 High High
cocaine 56 87.48 High High
Taxol 4 74.68 Quite High
drug abuse 114 55.44 Quite High
opiate 2 43.04 Quite Low
alcohol 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
Nucleus accumbens 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 10 98.68 Very High Very High Very High
Repression 1 85.76 High High
Sprains And Strains 10 76.52 Quite High
Drug Dependence 116 55.44 Quite High
Urological Neuroanatomy 2 36.16 Quite Low
Phencyclidine Abuse 8 24.84 Low Low
Obesity 8 11.68 Low Low
Cardiovascular Disease 18 10.52 Low Low
Stress 8 9.48 Low Low
Death 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of transcripts encoding the first specific step in the cholesterol biosynthetic pathway (FDFT1), the high-density lipoprotein (HDL) receptor (SCARB1) and an inhibitor of cholesterol biosynthesis (PRKAB1) were increased.
Gene_expression (Expression) of FDFT1 associated with disorder of lipid metabolism
1) Confidence 0.35 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.19 Pain Relevance 0.09
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Gene_expression (biosynthesis) of FDFT1 associated with disorder of lipid metabolism
2) Confidence 0.35 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.03
To do so, expression of the gene encoding squalene synthase (ERG9), the first committed step in sterol biosynthesis, can be down-regulated.
Gene_expression (expression) of squalene synthase
3) Confidence 0.03 Published 2009 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754923 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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