INT200949

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
UPF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 114 90.92 High High
cannabis 32 88.60 High High
cocaine 56 88.20 High High
Nucleus accumbens 4 77.12 Quite High
Hippocampus 2 76.24 Quite High
depression 4 72.16 Quite High
Morphine 2 36.88 Quite Low
alcohol 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 116 90.92 High High
Manic Depressive Disorder 2 73.00 Quite High
Depression 4 72.16 Quite High
Schizophrenia 4 71.68 Quite High
Brain Disease 2 71.68 Quite High
Cognitive Disorder 2 34.68 Quite Low
Cardiovascular Disease 18 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 10 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Overweight 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcripts for which expression was decreased were mainly associated with synaptic vesicular trafficking, clathrin-independent endocytosis or transport from the late endosome to the lysosome.
Negative_regulation (decreased) of Gene_expression (expression) of Transcripts
1) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.05 Pain Relevance 0.22
By classifying consistently regulated transcripts into biologically-relevant functional groups, we identified decreased expression of transcripts involved in calmodulin-related signaling and increased expression of transcripts involved in lipid/cholesterol metabolism and Golgi/ER-related function as being common molecular features involved in multiple patterns of human drug abuse.


Negative_regulation (decreased) of Gene_expression (expression) of transcripts associated with drug abuse
2) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.76 Pain Relevance 0.42

General Comments

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