INT200950

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FDFT1) oxidoreductase activity (FDFT1) endoplasmic reticulum (FDFT1)
transferase activity, transferring alkyl or aryl (other than methyl) groups (FDFT1)
FDFT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 57 59.92 Quite High
cocaine 28 50.00 Quite Low
cannabis 16 50.00 Quite Low
alcohol 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Nucleus accumbens 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5 98.56 Very High Very High Very High
Stress 33 95.04 Very High Very High Very High
Hypoxia 17 77.60 Quite High
Severe Acute Respiratory Syndrome 1 60.20 Quite High
Drug Dependence 58 59.92 Quite High
Cancer 7 58.24 Quite High
Metastasis 2 52.88 Quite High
Adenocarcinoma 3 51.36 Quite High
Breast Cancer 11 50.00 Quite Low
Lung Cancer 1 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Positive_regulation (increased) of FDFT1 associated with disorder of lipid metabolism
1) Confidence 0.29 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.03
Finally, transcripts of several enzymes of the cholesterol biosynthesis pathway (CYP51A1, FDFT1, HMGCR, SC4MOL, SC5DL) were marginally increased.


Positive_regulation (increased) of FDFT1
2) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.47 Pain Relevance 0

General Comments

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