INT200956

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CAMK2B) nucleoplasm (CAMK2B) microtubule organizing center (CAMK2B)
cytoplasm (CAMK2B) cytosol (CAMK2B) signal transduction (CAMK2B)
Anatomy Link Frequency
reticulum 1
CAMK2B (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 114 94.84 High High
cannabis 32 87.00 High High
cocaine 56 86.60 High High
addiction 6 75.04 Quite High
alcohol 8 61.76 Quite High
depression 4 34.44 Quite Low
Opioid 6 15.24 Low Low
Nucleus accumbens 4 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 116 94.84 High High
Phencyclidine Abuse 8 88.08 High High
Disorder Of Lipid Metabolism 10 78.88 Quite High
Cardiovascular Disease 18 68.16 Quite High
Obesity 8 65.28 Quite High
Alcohol Addiction 4 61.76 Quite High
Stress 6 57.92 Quite High
Pressure And Volume Under Development 2 50.40 Quite High
Disease 2 36.08 Quite Low
Suicidal Behaviour 2 34.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
34), representing a number of consistently changed functional classes: Calmodulin-related transcripts (CALM1, CALM2, CAMK2B) were decreased, while transcripts related to cholesterol biosynthesis and trafficking (FDFT1, APOL2, SCARB1), and Golgi/endoplasmic reticulum (ER) functions (SEMA3B, GCC1) were all increased.
Negative_regulation (re decrea) of CAMK2B in reticulum
1) Confidence 0.37 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762434 Disease Relevance 0.75 Pain Relevance 0.41
An additional 113 transcripts were significantly changed in Groups I–II only; 44 transcripts, including FIBP, VTN, STOM, ICAM1, SEMA3B, RARG, RARA, were increased, and 68 transcripts, including APOL1, CALM1, CALM2, CAMK2B, GNB2L1, HINT1, RAB9A, CHEK1, PPP2CA and NFKBIA, were decreased.
Negative_regulation (decreased) of CAMK2B
2) Confidence 0.12 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.18 Pain Relevance 0.15

General Comments

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