INT200963

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.18
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
Anatomy Link Frequency
brain 1
UPF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 145 99.84 Very High Very High Very High
cocaine 112 99.84 Very High Very High Very High
fluoxetine 55 99.84 Very High Very High Very High
drug abuse 228 99.68 Very High Very High Very High
cannabis 64 99.48 Very High Very High Very High
addiction 12 95.90 Very High Very High Very High
alcohol 16 95.68 Very High Very High Very High
Desipramine 60 93.72 High High
depression 23 91.04 High High
Hippocampus 9 87.20 High High
Disease Link Frequency Relevance Heat
Drug Dependence 232 99.68 Very High Very High Very High
Alcohol Addiction 8 95.90 Very High Very High Very High
Disorder Of Lipid Metabolism 20 95.04 Very High Very High Very High
Stress 27 92.56 High High
Depression 23 91.04 High High
Death 16 90.04 High High
Neuroblastoma 30 88.64 High High
Familial Dysautonomia 121 88.48 High High
Schizophrenia 8 49.84 Quite Low
Phencyclidine Abuse 16 34.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, previous studies in rodents have shown a differential regulation of distinct BDNF transcripts by antidepressant treatments [6,9,11].
Regulation (regulation) of transcripts associated with antidepressant
1) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.18 Pain Relevance 0.45
Recent rodent studies reported that antidepressant treatments affect the expression of brain-derived neurotrophic factor (BDNF) mRNA in a way that is dependent on treatment duration, by selective modulation of different BDNF transcripts.
Regulation (modulation) of transcripts in brain associated with antidepressant
2) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.16 Pain Relevance 0.32
The increasing knowledge of BDNF gene in rodents [7,8] has encouraged the research on the modulation of different BDNF transcripts by pharmacological treatments.
Regulation (modulation) of transcripts
3) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.32 Pain Relevance 0.24
These changes were accounted for by differential regulation of BDNF IV and VIa/b transcripts.
Regulation (regulation) of transcripts
4) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.15 Pain Relevance 0.50
Therefore, aim of the present study was to investigate whether antidepressant treatments of different time lengths induce changes in the expression of BDNF gene also in cultured human cells and to assess whether these modifications could be explained by differential regulation of BDNF transcripts.
Regulation (regulation) of transcripts associated with antidepressant
5) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.23 Pain Relevance 0.16
To identify transcripts that were similarly regulated by cocaine, cannabis and phencyclidine, we again employed GAP scores to examine 24 Group I–II cases with a confirmed drug abuse history and toxicological evidence of cocaine, cannabis or phencyclidine (COC+, THC+ and PCP+, respectively) present at death.
Regulation (regulated) of transcripts associated with cannabis, drug abuse, death and cocaine
6) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.26 Pain Relevance 0.39
While the exact nature of these differences could not be causally linked to specific ante or postmortem factors, alcohol dependence appeared to be a primary diagnosis for 5/8 Group III cases, which along with no or low concentrations of cocaine, cannabis or phencyclidine and significant other medical problems may have led to opposite regulation in Group III of the 89 transcripts shared among all three groups, of 91/115 transcripts changed in both Group I and Group III, and of 79/81 transcripts changed in both Groups II and III.
Regulation (regulation) of transcripts associated with addiction, cannabis, cocaine and alcohol
7) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.34
These differences may also underlie the opposite changes in the APOL1 and APOL2 transcripts in the drug abuse cases.
Regulation (changes) of transcripts associated with drug abuse
8) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.24
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Regulation (regulating) of transcripts associated with disorder of lipid metabolism
9) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.03
Although the mechanism by which kinetin modulate splicing remains poorly understood [36], [57], it is unlikely that kinetin acts directly on the general transcription machinery as the level of IKBKAP transcripts was not significantly modulated by kinetin in control hOE-MSCs (Figure 7G).
Neg (not) Regulation (modulated) of transcripts
10) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.35 Pain Relevance 0

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