INT200972

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.51
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
Anatomy Link Frequency
prefrontal 2
UPF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 112 95.72 Very High Very High Very High
Nucleus accumbens 8 94.40 High High
drug abuse 228 94.16 High High
cannabis 64 87.88 High High
fluoxetine 11 82.44 Quite High
Desipramine 12 81.84 Quite High
antidepressant 29 76.80 Quite High
depression 13 68.92 Quite High
opiate 4 43.04 Quite Low
Hippocampus 5 41.60 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 20 100.00 Very High Very High Very High
Schizophrenia 8 99.84 Very High Very High Very High
Drug Dependence 232 94.16 High High
Brain Disease 4 78.16 Quite High
Manic Depressive Disorder 4 69.76 Quite High
Depression 13 68.92 Quite High
Neuroblastoma 6 50.00 Quite Low
Urological Neuroanatomy 4 36.16 Quite Low
Cognitive Disorder 6 31.44 Quite Low
Phencyclidine Abuse 16 15.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How would you describe your perceptions and experiences with the advance rent system commonly practiced in Accra?
Positive_regulation (practiced) of Gene_expression (system) of advance rent
1) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
Study participants acknowledged that advance rent commitments create a major life struggle and frequently result in severe financial constraints for a range of household expenditures, including food, children’s school fees, and many basic necessities as they “try to save money for future advance rent”:
Positive_regulation (result) of Gene_expression (commitments) of advance rent
2) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
In addition, we analyzed the expression of the low-level BDNF transcripts, BDNF I, II, VIb-IXbd and VIIa/b; all drug treatments did not change the expression of the transcripts (data not shown).
Neg (not) Positive_regulation (change) of Gene_expression (expression) of transcripts
3) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0 Pain Relevance 0.37
By classifying consistently regulated transcripts into biologically-relevant functional groups, we identified decreased expression of transcripts involved in calmodulin-related signaling and increased expression of transcripts involved in lipid/cholesterol metabolism and Golgi/ER-related function as being common molecular features involved in multiple patterns of human drug abuse.


Positive_regulation (increased) of Gene_expression (expression) of transcripts associated with drug abuse
4) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.76 Pain Relevance 0.41
This is reminiscent of the situation in the prefrontal cortex in schizophrenia, where expression of APOL1, 2 and 4 transcripts were increased [35], and myelin transcripts were decreased [9].
Positive_regulation (increased) of Gene_expression (expression) of transcripts in prefrontal associated with schizophrenia
5) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.26 Pain Relevance 0.26
Expression of the LASS4, PTGES, ZDHHC1 and ZDHHC8 transcripts involved in lipid biosynthesis, metabolism and modification were all increased.


Positive_regulation (increased) of Gene_expression (Expression) of transcripts
6) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.30 Pain Relevance 0.10
Expression of transcripts encoding the first specific step in the cholesterol biosynthetic pathway (FDFT1), the high-density lipoprotein (HDL) receptor (SCARB1) and an inhibitor of cholesterol biosynthesis (PRKAB1) were increased.
Positive_regulation (increased) of Gene_expression (Expression) of transcripts associated with disorder of lipid metabolism
7) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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