INT200979

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.19
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
UPF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 58 100.00 Very High Very High Very High
fluoxetine 22 96.60 Very High Very High Very High
drug abuse 57 94.16 High High
Desipramine 24 88.12 High High
cannabis 16 87.16 High High
cocaine 28 86.76 High High
depression 9 70.72 Quite High
Serotonin 4 55.52 Quite High
headache 1 28.36 Quite Low
imagery 4 15.44 Low Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 242 99.84 Very High Very High Very High
Hypertension 4 96.60 Very High Very High Very High
Drug Dependence 58 94.16 High High
Brain Disease 1 78.16 Quite High
Neuroblastoma 12 75.00 Quite High
Manic Depressive Disorder 1 71.56 Quite High
Depression 9 70.72 Quite High
Schizophrenia 2 70.24 Quite High
Stress 18 61.12 Quite High
Anxiety Disorder 5 60.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another participant who borrowed her initial advance rent money and has yet to finish paying described how this might have resulted in her becoming hypertensive:
Regulation (borrowed) of Gene_expression (money) of advance rent associated with hypertension
1) Confidence 0.28 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0.28 Pain Relevance 0
This is the first study showing biphasic changes in the expression of total and specific BDNF transcripts in human cells following antidepressant treatments.
Regulation (changes) of Gene_expression (expression) of transcripts associated with antidepressant
2) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.15 Pain Relevance 0.49
To the best of our knowledge, this is the first study analyzing the effect of antidepressant treatments on the expression of BDNF transcripts in cells of human origin.
Spec (analyzing) Regulation (effect) of Gene_expression (expression) of transcripts associated with antidepressant
3) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0 Pain Relevance 0.40
By classifying consistently regulated transcripts into biologically-relevant functional groups, we identified decreased expression of transcripts involved in calmodulin-related signaling and increased expression of transcripts involved in lipid/cholesterol metabolism and Golgi/ER-related function as being common molecular features involved in multiple patterns of human drug abuse.


Regulation (involved) of Gene_expression (expression) of transcripts associated with drug abuse
4) Confidence 0.00 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.77 Pain Relevance 0.42
Since MU transcripts contain a premature stop codon that may activate the nonsense-mediated mRNA decay (NMD) pathway, we wanted to confirm whether this pathway is responsible for the lower IKBKAP transcripts expression in FD cells.
Spec (whether) Regulation (responsible) of Gene_expression (expression) of transcripts associated with familial dysautonomia
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.59 Pain Relevance 0
Using the hOE-MSCs model, we were also able to modulate the expression of IKBKAP WT and MU transcripts, by exposing the cells to different culture conditions to simulate variations in alternative splicing occurring during development and differentiation. hOE-MSCs form free floating spheres in approximately 7 days, when cultured with EGF and bFGF in serum-free medium.
Regulation (modulate) of Gene_expression (expression) of transcripts
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.40 Pain Relevance 0

General Comments

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