INT200980

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.84
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOL1) transport (APOL1) extracellular space (APOL1)
extracellular region (APOL1)
Anatomy Link Frequency
brain 1
APOL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 228 99.68 Very High Very High Very High
cocaine 112 94.24 High High
cannabis 64 76.36 Quite High
Nucleus accumbens 8 60.72 Quite High
opiate 4 31.52 Quite Low
alcohol 16 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Opioid 12 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Morphine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 20 100.00 Very High Very High Very High
Drug Dependence 232 99.68 Very High Very High Very High
Schizophrenia 8 49.84 Quite Low
Urological Neuroanatomy 4 24.64 Low Low
Phencyclidine Abuse 16 21.60 Low Low
Cardiovascular Disease 36 5.00 Very Low Very Low Very Low
Death 16 5.00 Very Low Very Low Very Low
Overweight 16 5.00 Very Low Very Low Very Low
Obesity 16 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular note were increases in the apoliprotein L (APOL) transcripts, for which the increased expression of APOL2 was validated by QPCR (Fig. 3).
Transcription (transcripts) of APOL
1) Confidence 0.67 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.10
The APOL2 transcript is most highly expressed in brain, while the APOL1 transcript differs from other APOL transcripts by an additional exon that produces a secreted APOL protein [30].
Transcription (transcript) of APOL1 in brain
2) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.22 Pain Relevance 0.17
These differences may also underlie the opposite changes in the APOL1 and APOL2 transcripts in the drug abuse cases.
Transcription (transcripts) of APOL1 associated with drug abuse
3) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.24
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Transcription (transcription) of apolipoprotein APOL1 associated with disorder of lipid metabolism
4) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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