INT200982

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.94
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CALM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cannabis 48 99.16 Very High Very High Very High
cocaine 84 98.96 Very High Very High Very High
drug abuse 171 88.16 High High
addiction 9 47.68 Quite Low
alcohol 12 6.16 Low Low
Opioid 9 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Nucleus accumbens 6 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
Morphine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 9 94.68 High High
Obesity 12 91.36 High High
Cardiovascular Disease 27 90.20 High High
Drug Dependence 174 88.16 High High
Disorder Of Lipid Metabolism 15 84.52 Quite High
Phencyclidine Abuse 12 67.24 Quite High
Death 12 43.72 Quite Low
Alcohol Addiction 6 6.60 Low Low
Overweight 12 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, humans who abused cocaine, cannabis and/or phencyclidine share a decrease in transcription of calmodulin-related genes and increased transcription related to lipid/cholesterol and Golgi/ER function.
Transcription (transcription) of calmodulin associated with cannabis and cocaine
1) Confidence 0.48 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762434 Disease Relevance 0.64 Pain Relevance 0.34
A general decrease was observed for calcium/calmodulin-regulated transcripts (CALM1, CALM2, CAMK2B, S100A16) and a transcript encoding a phosphatase putatively involved in cAMP biosynthesis and adenylate cyclase (AC) activity (THTPA).


Transcription (transcripts) of CALM1
2) Confidence 0.48 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.14
A general decrease was observed for calcium/calmodulin-regulated transcripts (CALM1, CALM2, CAMK2B, S100A16) and a transcript encoding a phosphatase putatively involved in cAMP biosynthesis and adenylate cyclase (AC) activity (THTPA).


Transcription (transcripts) of calmodulin
3) Confidence 0.48 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.14

General Comments

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