INT200986

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOL1) transport (APOL1) extracellular space (APOL1)
extracellular region (APOL1)
Anatomy Link Frequency
prefrontal 2
APOL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 28 95.72 Very High Very High Very High
Nucleus accumbens 2 94.40 High High
drug abuse 57 84.88 Quite High
cannabis 16 50.00 Quite Low
Hippocampus 1 41.60 Quite Low
alcohol 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 2 99.84 Very High Very High Very High
Drug Dependence 58 84.88 Quite High
Disorder Of Lipid Metabolism 5 43.68 Quite Low
Cardiovascular Disease 9 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Overweight 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Phencyclidine Abuse 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is reminiscent of the situation in the prefrontal cortex in schizophrenia, where expression of APOL1, 2 and 4 transcripts were increased [35], and myelin transcripts were decreased [9].
Positive_regulation (increased) of Gene_expression (expression) of APOL1 in prefrontal associated with schizophrenia
1) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.26 Pain Relevance 0.26

General Comments

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