INT20100

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Context Info
Confidence 0.29
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 6.78
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
coronary artery 1
chest 1
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 22 97.78 Very High Very High Very High
aspirin 20 95.62 Very High Very High Very High
Pain 2 93.38 High High
alcohol 10 90.96 High High
bradykinin 8 90.64 High High
antagonist 5 90.08 High High
Onset of action 1 79.76 Quite High
Dismenorea 2 58.56 Quite High
metalloproteinase 6 51.52 Quite High
cytokine 7 50.36 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 201 99.50 Very High Very High Very High
Cardiovascular Disease 28 99.20 Very High Very High Very High
Coronary Artery Disease 60 99.00 Very High Very High Very High
Syndrome 1 98.06 Very High Very High Very High
Angina 6 97.78 Very High Very High Very High
Stable Angina Pectoris 1 94.76 High High
Acute Coronary Syndrome 53 94.60 High High
Pain 1 93.38 High High
Cv General 3 Under Development 23 91.56 High High
Obesity 10 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To exclude age dependent or pain related influences, age-matched patients with stable angina pectoris (NHYA II) and angiographically proven coronary artery disease (CAD, n = 16) or without evidence for coronary sclerosis (variant angina, n = 10; angina-like syndrome with normal coronary angiogram, n = 5; non-CAD, n = 15) have been investigated for their plasma PAI-1 activity and t-PA antigen levels.
PAI Binding (activity) of in coronary artery associated with stable angina pectoris, pain, angina, coronary artery disease and syndrome
1) Confidence 0.29 Published 1990 Journal Thromb. Haemost. Section Abstract Doc Link 2119522 Disease Relevance 1.74 Pain Relevance 0.54
Other factors included in the plasminogen/plasmin and fibrinolytic system, such as tPA, uPA and PAI-1, can participate in the tissue remodelling of the ECM directly through the binding to specific receptors, and through the transformation of the plasminogen precursor bound to the cell surface to plasmin, which is an active serine protease.
PAI-1 Binding (binding) of
2) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.06 Pain Relevance 0.11
Controlling for these known risk factors made no material difference in the odds ratios and corresponding confidence intervals related to the ACE and PAI-1 interaction.
PAI-1 Binding (interaction) of
3) Confidence 0.20 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.68 Pain Relevance 0.18
CONCLUSIONS: Although it has been suggested that alterations in local (transmyocardial) t-PA and PAI-1 activities may be of pathophysiologic importance in the genesis of unstable angina, our data show no difference in transmyocardial fibrinolytic activity in patients with unstable angina, stable angina, and noncardiac chest pain.


PAI-1 Binding (alterations) of in chest
4) Confidence 0.18 Published 1996 Journal Coron. Artery Dis. Section Body Doc Link 8773432 Disease Relevance 0 Pain Relevance 0
We examined the association of PAI-1 4G/5G genotype and CVD events in the elderly participants of the Cardiovascular Health Study (CHS).
PAI-1 Spec (examined) Binding (association) of associated with cardiovascular disease
5) Confidence 0.18 Published 2003 Journal J. Thromb. Haemost. Section Abstract Doc Link 12911596 Disease Relevance 0.75 Pain Relevance 0.08
CONCLUSION: Hypofibrinolysis, associated with the 4G allele of the PAI-1 gene, was found significantly more often in women with endometriosis compared with controls.
PAI-1 gene Binding (associated) of
6) Confidence 0.18 Published 2006 Journal Obstet Gynecol Section Body Doc Link 16816071 Disease Relevance 0.06 Pain Relevance 0
Based on this final model, there was a significant interaction between the ACE and PAI-1 polymorphisms (p = 0.02).


PAI-1 Binding (interaction) of
7) Confidence 0.15 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.09 Pain Relevance 0
Although the original analysis suggested a marginally significant interaction between the ACE and PAI-1 polymorphisms on the risk of MI, the minimum prediction error of 46.2% is not significantly lower than the value of 50% that would be expected by chance (p = 0.15).
PAI-1 Binding (interaction) of associated with myocardial infarction
8) Confidence 0.15 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.25 Pain Relevance 0
Table 2 shows the relationship between the ACE DD genotype (versus not DD) and risk of MI, separately for the two PAI-1 groupings based on both analyses.
PAI-1 Binding (groupings) of associated with myocardial infarction
9) Confidence 0.15 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.48 Pain Relevance 0
In fact, we obtained a significant interaction between the ACE and PAI-1 polymorphisms on risk of MI using both methods.
PAI-1 Binding (interaction) of associated with myocardial infarction
10) Confidence 0.15 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.10 Pain Relevance 0
However, the conclusions obtained from the two methods were consistent with both suggesting a possible interaction between the ACE I/D and PAI-1 4G/5G polymorphisms on the risk of MI.
PAI-1 4G Binding (interaction) of associated with myocardial infarction
11) Confidence 0.15 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.46 Pain Relevance 0
We used data from 343 matched case-control pairs in the Physicians' Health Study (PHS) to examine possible interactions among the bi-allelic ACE I/D, PAI-1 4G/5G, and t-PA I/D polymorphisms on the risk of MI.
PAI-1 4G Binding (interactions) of associated with myocardial infarction
12) Confidence 0.15 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.46 Pain Relevance 0.05
In the current study, a total of 19 parameters must be estimated in the maximum conditional logistic regression model under consideration, which considers all possible main effects and two-way interactions among three polymorphisms with three genotypes each (1 for the intercept, 2 each for the main effects of ACE, PAI-1, and t-PA, and 4 each for the ACE × PAI-1, ACE × t-PA, and PAI-1 × t-PA interactions).
PAI-1 Binding (interactions) of
13) Confidence 0.13 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.13 Pain Relevance 0.03
Associations of fibrinogen, factor VII and PAI-1 with baseline findings among 10,500 male participants in a prospective study of myocardial infarction--the PRIME Study.
PAI-1 Binding (Associations) of associated with myocardial infarction
14) Confidence 0.09 Published 1998 Journal Thromb. Haemost. Section Title Doc Link 9843166 Disease Relevance 0.84 Pain Relevance 0.06
The associations of PAI-1 activity and PAI-1 antigen with risk of events disappeared after adjustment for parameters reflecting insulin resistance but were not affected by other adjustments.
PAI-1 Binding (associations) of
15) Confidence 0.07 Published 1996 Journal Circulation Section Body Doc Link 8901651 Disease Relevance 0.06 Pain Relevance 0
The associations of PAI-1 activity and PAI-1 antigen with risk of events disappeared after adjustment for parameters reflecting insulin resistance but were not affected by other adjustments.
PAI-1 Binding (associations) of
16) Confidence 0.07 Published 1996 Journal Circulation Section Body Doc Link 8901651 Disease Relevance 0.06 Pain Relevance 0
The current standard of care for ACS patients is dual antiplatelet therapy with aspirin and clopidogrel, although studies show that newer P2Y12 inhibitors, including prasugrel and ticagrelor, are more effective than clopidogrel.26,27 Limitations of clopidogrel include relatively slow onset of effect, low PAI in many patients, inter-individual variability in response, and irreversible P2Y12 binding that prevents rapid offset of effect.
PAI Binding (binding) of associated with aspirin and acute coronary syndrome
17) Confidence 0.01 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966970 Disease Relevance 0.57 Pain Relevance 0.13

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