INT201005

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.66
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOL1) transport (APOL1) extracellular space (APOL1)
extracellular region (APOL1)
Anatomy Link Frequency
blood 1
prefrontal 1
APOL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 84 95.72 Very High Very High Very High
Nucleus accumbens 6 94.40 High High
drug abuse 171 82.00 Quite High
cannabis 48 68.04 Quite High
Hippocampus 3 38.72 Quite Low
opiate 3 23.20 Low Low
cytokine 71 5.00 Very Low Very Low Very Low
Inflammation 55 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
alcohol 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 88 100.00 Very High Very High Very High
Schizophrenia 6 99.84 Very High Very High Very High
Disease 156 99.70 Very High Very High Very High
Increased Venous Pressure Under Development 47 99.00 Very High Very High Very High
Systemic Sclerosis 107 97.56 Very High Very High Very High
Targeted Disruption 15 95.92 Very High Very High Very High
African Trypanosomiasis 110 95.80 Very High Very High Very High
Infection 266 92.92 High High
Cardiovascular Disease 83 88.72 High High
Trypanosomiasis 155 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The six known APOL genes are exclusively present in primates, with the APOL1-4 genes forming a tight cluster on human chromosome 22q13.1 [30].
Gene_expression (present) of APOL
1) Confidence 0.75 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.13
In case of T. rhodesiense the resistance to the trypanolytic capacity of APOL-1 is due to the expression of serum resistance-associated (SRA) protein [94] which neutralizes APOL1 through the interaction with the C-terminal of this lipoprotein.
Gene_expression (expression) of APOL1
2) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.47 Pain Relevance 0
kDa high-density lipoprotein complex composed of apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), apoliprotein L-I (APOL1), human cathelicidin antimicrobial peptide (hCAP18), GPI-specific phospholipase D (GPI-PLD), apolipoprotein A-II, and paraoxanase [106, 110], and (ii) TLF2, a 1000?
Gene_expression (composed) of APOL1 associated with disorder of lipid metabolism
3) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.46 Pain Relevance 0
kDa high-density lipoprotein complex composed of apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), apoliprotein L-I (APOL1), human cathelicidin antimicrobial peptide (hCAP18), GPI-specific phospholipase D (GPI-PLD), apolipoprotein A-II, and paraoxanase [106, 110], and (ii) TLF2, a 1000?
Gene_expression (composed) of apoliprotein L-I associated with disorder of lipid metabolism
4) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.46 Pain Relevance 0
This is reminiscent of the situation in the prefrontal cortex in schizophrenia, where expression of APOL1, 2 and 4 transcripts were increased [35], and myelin transcripts were decreased [9].
Gene_expression (expression) of APOL1 in prefrontal associated with schizophrenia
5) Confidence 0.55 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.26 Pain Relevance 0.26
APOL1 is only found in the sera from humans and gorilla which have the trypanolytic capacity but not in the chimpanzee serum which lacks the trypanolytic potential [89].
Neg (not) Gene_expression (found) of APOL1
6) Confidence 0.53 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.34 Pain Relevance 0
The six known APOL genes are exclusively present in primates, with the APOL1-4 genes forming a tight cluster on human chromosome 22q13.1 [30].
Gene_expression (present) of APOL1
7) Confidence 0.48 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.14
Others have shown three human apolipoproteins (Hpr, APOA1, and APOL1) acting cooperatively for maximal killing capacity; however; the truncated APOL1 did not function in transgenic animal [118].
Gene_expression (shown) of APOL1 associated with targeted disruption
8) Confidence 0.26 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.45 Pain Relevance 0
FMD negatively correlated with disease duration, the levels of apolipoprotein A1, the paraoxonase-1 activity, and systolic blood pressure in MCTD patients.
Gene_expression (levels) of apolipoprotein A1 in blood associated with systemic sclerosis, disease, increased venous pressure under development and disorder of lipid metabolism
9) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911856 Disease Relevance 1.78 Pain Relevance 0

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