INT201010

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 2.73
Pain Relevance 1.57

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Anatomy Link Frequency
reticulum 1
CALM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 285 95.12 Very High Very High Very High
cocaine 140 92.88 High High
cannabis 80 92.52 High High
addiction 15 75.32 Quite High
opiate 5 63.92 Quite High
alcohol 20 61.76 Quite High
depression 10 34.72 Quite Low
Opioid 15 15.52 Low Low
Nucleus accumbens 10 5.00 Very Low Very Low Very Low
Morphine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 25 99.04 Very High Very High Very High
Drug Dependence 290 95.12 Very High Very High Very High
Phencyclidine Abuse 20 88.36 High High
Cardiovascular Disease 45 87.36 High High
Obesity 20 84.48 Quite High
Stress 15 77.12 Quite High
Alcohol Addiction 10 61.76 Quite High
Urological Neuroanatomy 5 57.04 Quite High
Pressure And Volume Under Development 5 50.68 Quite High
Disease 5 36.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative PCR validated decreases in calmodulin 2 (CALM2) mRNA and increases in apolipoprotein L, 2 (APOL2) and semaphorin 3B (SEMA3B) mRNA for individual cases.
Negative_regulation (decreases) of calmodulin 2 associated with disorder of lipid metabolism
1) Confidence 0.34 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762434 Disease Relevance 0.83 Pain Relevance 0.43
Quantitative PCR validated decreases in calmodulin 2 (CALM2) mRNA and increases in apolipoprotein L, 2 (APOL2) and semaphorin 3B (SEMA3B) mRNA for individual cases.
Negative_regulation (decreases) of CALM2 associated with disorder of lipid metabolism
2) Confidence 0.34 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762434 Disease Relevance 0.83 Pain Relevance 0.43
34), representing a number of consistently changed functional classes: Calmodulin-related transcripts (CALM1, CALM2, CAMK2B) were decreased, while transcripts related to cholesterol biosynthesis and trafficking (FDFT1, APOL2, SCARB1), and Golgi/endoplasmic reticulum (ER) functions (SEMA3B, GCC1) were all increased.
Negative_regulation (re decrea) of CALM2 in reticulum
3) Confidence 0.20 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762434 Disease Relevance 0.76 Pain Relevance 0.42
The significant decrease in CALM1, CALM2 and CAMKIIB transcripts suggest that altered regulation of neuroplasticity and dendritic architecture by calmodulin-regulated pathways could be a common theme in human abuse of cocaine, cannabis and/or phencyclidine.


Negative_regulation (decrease) of CALM2 associated with cannabis and cocaine
4) Confidence 0.15 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.14 Pain Relevance 0.16
An additional 113 transcripts were significantly changed in Groups I–II only; 44 transcripts, including FIBP, VTN, STOM, ICAM1, SEMA3B, RARG, RARA, were increased, and 68 transcripts, including APOL1, CALM1, CALM2, CAMK2B, GNB2L1, HINT1, RAB9A, CHEK1, PPP2CA and NFKBIA, were decreased.
Negative_regulation (decreased) of CALM2
5) Confidence 0.15 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.18 Pain Relevance 0.15

General Comments

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