INT201016

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (AP2B1) cytosol (AP2B1) vesicle-mediated transport (AP2B1)
plasma membrane (AP2B1)
Anatomy Link Frequency
plasma 1
AP2B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 57 69.56 Quite High
cannabis 16 51.88 Quite High
cocaine 28 51.48 Quite High
alcohol 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Nucleus accumbens 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 168 98.52 Very High Very High Very High
Targeted Disruption 8 72.00 Quite High
Dengue 22 71.20 Quite High
Drug Dependence 58 69.56 Quite High
Phencyclidine Abuse 4 52.80 Quite High
Disorder Of Lipid Metabolism 5 40.48 Quite Low
Death 6 29.28 Quite Low
Hepatocellular Cancer 2 15.76 Low Low
Disease 7 9.20 Low Low
Dengue Hemorrhagic Fever 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoclonal antibodies specific for the cellular proteins, CLTC (Sigma Aldrich), AP2B1 (Abcam), DNM2 (Sigma Aldrich), ARRB1 (Abnova), ATP6V0A1 (Sigma Aldrich) and ARPC1B (Santa Cruz Biotechnology) were used for Western detection.
Positive_regulation (used) of AP2B1
1) Confidence 0.36 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.08 Pain Relevance 0
It can be observed that at least one of the four siRNAs directed against each specific gene (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B) can result in more than 50% inhibition of DENV infection (Figure 3G) hence indicating the specificity of these genes in mediating DENV infection.
Positive_regulation (result) of AP2B1 associated with infection
2) Confidence 0.15 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.81 Pain Relevance 0
Also increased were transcripts encoding adaptins and an adaptin kinase (AP1M2, AP2A1, AP4B1, AAK1) associated with clathrin-coated vesicle endocytosis at the plasma membrane and in transport between the Golgi apparatus and the endosomal system.
Positive_regulation (increased) of adaptin kinase in plasma
3) Confidence 0.02 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.12 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox