INT201019

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOL1) transport (APOL1) extracellular space (APOL1)
extracellular region (APOL1)
Anatomy Link Frequency
brain 1
APOL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
drug abuse 114 91.52 High High
cocaine 56 86.40 High High
cannabis 32 56.60 Quite High
Nucleus accumbens 4 52.88 Quite High
opiate 2 11.76 Low Low
cytokine 28 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 34 100.00 Very High Very High Very High
Drug Dependence 116 91.52 High High
Schizophrenia 4 42.00 Quite Low
Phencyclidine Abuse 8 20.76 Low Low
Targeted Disruption 6 7.84 Low Low
Infection 106 5.00 Very Low Very Low Very Low
Trypanosomiasis 62 5.00 Very Low Very Low Very Low
Disease 54 5.00 Very Low Very Low Very Low
African Trypanosomiasis 44 5.00 Very Low Very Low Very Low
Parasitemia 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
kDa high-density lipoprotein complex composed of apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), apoliprotein L-I (APOL1), human cathelicidin antimicrobial peptide (hCAP18), GPI-specific phospholipase D (GPI-PLD), apolipoprotein A-II, and paraoxanase [106, 110], and (ii) TLF2, a 1000?
Localization (phospholipase D) of APOL1 associated with disorder of lipid metabolism
1) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.45 Pain Relevance 0
kDa high-density lipoprotein complex composed of apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), apoliprotein L-I (APOL1), human cathelicidin antimicrobial peptide (hCAP18), GPI-specific phospholipase D (GPI-PLD), apolipoprotein A-II, and paraoxanase [106, 110], and (ii) TLF2, a 1000?
Localization (phospholipase D) of apoliprotein L-I associated with disorder of lipid metabolism
2) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.45 Pain Relevance 0
The APOL2 transcript is most highly expressed in brain, while the APOL1 transcript differs from other APOL transcripts by an additional exon that produces a secreted APOL protein [30].
Localization (secreted) of APOL protein in brain
3) Confidence 0.57 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.20
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Localization (secreted) of apolipoprotein APOL1 associated with disorder of lipid metabolism
4) Confidence 0.50 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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