INT20102

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 1
Speculated 5
Reported most in Body
Documents 102
Total Number 108
Disease Relevance 65.99
Pain Relevance 12.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
astrocytes 11
Plasma 9
platelet 6
brain 4
plaque 4
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 128 100.00 Very High Very High Very High
ischemia 107 99.00 Very High Very High Very High
Snapping jaw 7 98.92 Very High Very High Very High
antidepressant 168 98.86 Very High Very High Very High
agonist 420 98.78 Very High Very High Very High
Central nervous system 164 98.76 Very High Very High Very High
Angina 63 98.44 Very High Very High Very High
Arthritis 108 98.32 Very High Very High Very High
fibrosis 344 98.20 Very High Very High Very High
COX-2 inhibitor 8 98.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 75 100.00 Very High Very High Very High
Hypothermia 782 99.78 Very High Very High Very High
Stroke 501 99.78 Very High Very High Very High
Breast Cancer 154 99.76 Very High Very High Very High
Coronary Artery Disease 65 99.74 Very High Very High Very High
Metastasis 70 99.52 Very High Very High Very High
Injury 115 99.44 Very High Very High Very High
Disorder Of Lipid Metabolism 800 99.40 Very High Very High Very High
Hypertension 117 99.40 Very High Very High Very High
Endotoxemia 357 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we have reported that PAI-1 gene expression was markedly enhanced locally in cardiovascular cells immediately after injecting (i.p.) mice with kainate, an analog of glutamate, which is the principal excitatory neurotransmitter in the central nervous system.
Gene_expression (expression) of PAI-1 gene in central nervous system associated with neurotransmitter, glutamate and central nervous system
1) Confidence 0.78 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.10 Pain Relevance 0.14
In brain, tissue plasminogen activator (tPA) expression in astrocytes is the primary source of plasminogen activator and PAI-1 is the dominant inhibitor of tPA [21].
Gene_expression (source) of PAI in astrocytes
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.52 Pain Relevance 0.18
Stroke significantly increased expression of tPA and PAI-1 in the ischemic hemisphere compared to non-ischemic brain (Fig. 4a, 4b).
Gene_expression (expression) of PAI in brain associated with stroke
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.75 Pain Relevance 0
As a member of the serpine gene family, PAI-1 is the major inhibitor of tPA [21], and is largely produced by reactive astrocytes in the CNS after stroke [65], [66].
Gene_expression (produced) of PAI in astrocytes associated with stroke and central nervous system
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.43 Pain Relevance 0.09
Therefore, we hypothesize that MSCs decrease PAI-1 expression and stimulate tPA after ischemia and thereby promote neurite remodeling.
Gene_expression (expression) of PAI in neurite associated with ischemia
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.66 Pain Relevance 0.17
PAI-1 gene expression was monitored in the heart via in situ hybridization using (35)S-labeled PAI-1-specific riboprobes.
Gene_expression (expression) of PAI-1 gene in heart
6) Confidence 0.67 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.08 Pain Relevance 0.28
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis.
Gene_expression (function) of plasminogen activator inhibitor-1
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2836381 Disease Relevance 0.15 Pain Relevance 0
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis.
Gene_expression (function) of PAI-1
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2836381 Disease Relevance 0.15 Pain Relevance 0
In this study, we measured tPA/PAI-1 expression and tPA activity in astrocytes cultured under normal and oxygen and glucose deprivation (OGD) conditions and co-cultured with or without MSCs as an in vitro ischemia model.
Gene_expression (expression) of PAI in astrocytes associated with ischemia
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.67 Pain Relevance 0.17
Both growth promoting and growth-inhibitory molecules are upregulated within the peri-infarct region of the brain early after stroke [69]. tPA expression as well as its inhibitors PAI-1 and neuroserpin are up-regulated in the acute stage of cerebral ischemia and hemorrhage [13], [70], [71].
Gene_expression (expression) of PAI in brain associated with cv general 4 under development, stroke, ischemia and cva
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.91 Pain Relevance 0.16
MSCs reduce PAI-1 in reactive astrocytes, which thereby increase tPA activity.
Gene_expression (reduce) of PAI in astrocytes
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.39 Pain Relevance 0.06
This view is supported by the significant increase in circulating PAI-Ag levels at temperatures of 34°C and 31°C versus 37°C in endotoxemic animals, and the most pronounced endothelial expression of PAI-1 during 31°C hypothermia.
Gene_expression (expression) of PAI associated with hypothermia
12) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.02 Pain Relevance 0
In general, P-selectin and PAI-1 were expressed within the endothelium of arterioles and venules, while little, if any, immunoreactivity was detected within the surrounding muscle tissue.
Neg (little) Gene_expression (expressed) of PAI in endothelium
13) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.12 Pain Relevance 0
Endotoxemia resulted in a marked increase in the expression of P-selectin and PAI-1 within the microvascular endothelium.
Gene_expression (expression) of PAI in endothelium associated with endotoxemia
14) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.46 Pain Relevance 0
For the first time, we now provide evidence that the expression of PAI-1 is increased in the systemic circulation and thrombus formation in endotoxemia is enhanced by moderate systemic hypothermia.
Gene_expression (expression) of PAI associated with hypothermia, endotoxemia and thrombosis
15) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.95 Pain Relevance 0
When PAI-1 expression was restored, invasion and associated angiogenesis were also restored, suggesting that host-produced PAI-1 is essential for cancer cell invasion and angiogenesis [10].
Gene_expression (expression) of PAI-1 associated with cancer
16) Confidence 0.65 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.51 Pain Relevance 0
We carried out experiments to investigate whether the COX-2 inhibitor celecoxib at a dose of either 200 mg bid or 400 mg bid could significantly affect endogenous uPA, PAI-1 or PGE2 production in women at increased risk for breast cancer.
Gene_expression (production) of PAI-1 associated with breast cancer and cox-2 inhibitor
17) Confidence 0.65 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.17 Pain Relevance 0.05
These data indicate that astrocytes in the IBZ respond to MSC treatment and increase tPA and concomitantly decrease PAI-1 gene expression.


Gene_expression (expression) of PAI in astrocytes
18) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.62 Pain Relevance 0
In vitro, MSCs significantly increased tPA levels and concomitantly reduced plasminogen activator inhibitor 1 (PAI-1) expression in astrocytes under normal and oxygen and glucose deprivation (OGD) conditions.
Gene_expression (expression) of plasminogen activator inhibitor in astrocytes
19) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815778 Disease Relevance 0.40 Pain Relevance 0.08
, as well as other chemicals/agents, induce PAI-1 expression in cultured cells and in vivo [68].
Gene_expression (expression) of PAI
20) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.71 Pain Relevance 0.14

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