INT201049

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.25
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC5A5) small molecule metabolic process (SLC5A5) plasma membrane (SLC5A5)
nucleus (SLC5A5) cellular nitrogen compound metabolic process (SLC5A5) transmembrane transport (SLC5A5)
Anatomy Link Frequency
thyroid 1
SLC5A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 12 59.00 Quite High
Inflammation 14 26.68 Quite Low
cytokine 4 22.16 Low Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Hepatitis C Virus Infection 115 99.76 Very High Very High Very High
Nicotine Addiction 24 98.00 Very High Very High Very High
Hyperthyroidism 9 97.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 84.40 Quite High
Thyroid Disease 27 63.20 Quite High
Thyroid Neoplasm 6 60.44 Quite High
Liver Disease 10 55.76 Quite High
Infection 79 50.68 Quite High
Ovarian Cancer 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies indicate that perchlorate is a more potent inhibitor of human NIS, with potencies 15, 30, and 240 times greater than thiocyanate, iodide, and nitrate, respectively (Tonacchera et al. 2004).
Negative_regulation (inhibitor) of NIS
1) Confidence 0.05 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764147 Disease Relevance 0.37 Pain Relevance 0.03
g/L, urinary thiocyanate was negatively associated with serum TSH, a direction unexpected based on a mechanism of NIS inhibition.
Negative_regulation (inhibition) of NIS
2) Confidence 0.05 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764147 Disease Relevance 0.29 Pain Relevance 0
Thiocyanate-induced NIS inhibition is a plausible explanation of the association of smoking with goiter in populations with low iodine intake (Knudsen et al. 2002) and is analogous to the association of perchlorate exposure with thyroid hormone levels observed in our study.
Negative_regulation (inhibition) of NIS in thyroid associated with nicotine addiction and hyperthyroidism
3) Confidence 0.05 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764147 Disease Relevance 0.43 Pain Relevance 0
1 kb element, the USF1 response element is critical to PTTG1 whereas PBF requires the USF1/PAX8 complex for repression of NIS.


Negative_regulation (repression) of NIS associated with repression
4) Confidence 0.02 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.22 Pain Relevance 0
HCV antiviral development involves all three of classes, HCV protease inhibitors (PIs), nucleoside HCV polymerase inhibitors (NIs), and nonnucleoside HCV polymerase inhibitors (NNIs).
Negative_regulation (inhibitors) of NIs associated with hepatitis c virus infection
5) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731021 Disease Relevance 0.94 Pain Relevance 0

General Comments

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