INT201067

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.36
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) aging (Ednra) extracellular region (Edn1)
plasma membrane (Ednra) signal transducer activity (Ednra) cell-cell signaling (Edn1)
Edn1 (Rattus norvegicus)
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 67 98.04 Very High Very High Very High
antagonist 127 93.92 High High
qutenza 42 83.64 Quite High
ischemia 16 77.52 Quite High
Calcitonin gene-related peptide 117 57.72 Quite High
Potency 9 50.48 Quite High
Neurotransmitter 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intestinal Obstruction 2 98.92 Very High Very High Very High
Wound Healing 11 82.84 Quite High
Increased Venous Pressure Under Development 11 80.36 Quite High
Adhesions 23 78.96 Quite High
Cv Unclassified Under Development 16 77.52 Quite High
Hypertension 5 74.04 Quite High
Appetite Loss 1 64.12 Quite High
Infection 2 62.76 Quite High
Disease 12 62.24 Quite High
Peritonitis 1 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has therefore been proposed that several parts of ET-1 interact with distinct sites on the ETA-receptor[15], [17].
ET-1 Binding (interact) of ETA-receptor
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.06 Pain Relevance 0.28
These findings combined with earlier models of ETA-receptor function [15], [17] can be integrated into a model regarding ET-1/ETA-interactions and ETA-mediated signaling as depicted in Fig. 7.
ET-1 Binding (regarding) of ETA-receptor
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.37
Ligand-binding studies and analyses of structure-affinity and structure-selectivity relationships previously indicated quasi-irreversible and polyvalent binding of ET-1 to ETA-receptors[2], [5], [15], [17], [44], [45].
ET-1 Binding (binding) of ETA
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.19 Pain Relevance 0.30
Three types of endothelin receptors, ETA, ETB, and ETC have been identified.
endothelin Binding (receptors) of ETA
4) Confidence 0.10 Published 2006 Journal World J Emerg Surg Section Body Doc Link PMC1764411 Disease Relevance 1.12 Pain Relevance 0.23

General Comments

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