INT201142

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sox2) anatomical structure formation involved in morphogenesis (Sox2) nucleus (Sox2)
DNA binding (Sox2) transcription factor binding (Sox2) cytoplasm (Sox2)
Anatomy Link Frequency
margin 2
Sox2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 40.68 Quite Low
imagery 40 25.76 Quite Low
ketamine 5 22.24 Low Low
Action potential 4 10.16 Low Low
Calcium channel 8 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 320 98.08 Very High Very High Very High
Myocardial Infarction 108 74.44 Quite High
Coronary Heart Disease 12 46.56 Quite Low
Cv Unclassified Under Development 20 43.52 Quite Low
Body Weight 4 35.52 Quite Low
Ganglion Cysts 2 6.16 Low Low
Hypertension 8 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In testing the principle that a stability margin must be broached for cellular uncoupling to occur, we found that decreasing LCC-RyR coupling efficiency by a factor other than hypertrophy obeyed the same principle.
Negative_regulation (decreasing) of LCC in margin associated with hypertrophy
1) Confidence 0.57 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.16 Pain Relevance 0
Therefore, whether the defective LCC-RyR coupling involves RyR modification is still under debate.
Spec (whether) Negative_regulation (defective) of LCC
2) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.28 Pain Relevance 0
When LCC unitary current was linearly modulated by membrane voltage [9], the decrease of LCC-RyR coupling efficiency resulted in a sigmoid relationship between membrane voltage and Ca2+ transient amplitude (Figure S2B), with the stability margin (light-colored bands in Figure S2B) agreeing well with the simulated result (gray bands in Figure 6F).
Negative_regulation (decrease) of LCC in margin
3) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0 Pain Relevance 0
However, with further decrease of LCC-RyR coupling efficiency, an increasing fraction of CRUs tends not to be activated before ICa inactivation (Figure 5B; green, blue, and black lines in Figure 6C); global performance of Ca2+ release declines.
Negative_regulation (decrease) of LCC
4) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.15 Pain Relevance 0
Analysis of RNA synthesis in RPCs using RT-PCR revealed marked down-regulation of Pax6, Hes1, B3-tubulin, DCX and partial down-regulation of nestin and Sox2 (Fig. 4).
Negative_regulation (down-regulation) of Sox2
5) Confidence 0.32 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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