INT201143

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.71
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sox2) anatomical structure formation involved in morphogenesis (Sox2) nucleus (Sox2)
DNA binding (Sox2) transcription factor binding (Sox2) cytoplasm (Sox2)
Anatomy Link Frequency
stem cell 1
Sox2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 97.76 Very High Very High Very High
antagonist 3 79.24 Quite High
imagery 31 78.80 Quite High
agonist 3 72.36 Quite High
Action potential 3 60.60 Quite High
depression 3 14.92 Low Low
fibrosis 3 10.72 Low Low
bDMF 49 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 240 99.08 Very High Very High Very High
Brain Tumor 60 97.88 Very High Very High Very High
Glioma 45 96.96 Very High Very High Very High
Myocardial Infarction 81 96.72 Very High Very High Very High
Malignant Neoplastic Disease 5 96.08 Very High Very High Very High
Cancer 72 94.60 High High
Glioblastoma 18 94.20 High High
Targeted Disruption 14 89.92 High High
Stress 8 77.52 Quite High
Hypertension 6 44.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then examined the probability of LCC-RyR coupling.
Regulation (probability) of LCC
1) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.58 Pain Relevance 0.11
How then, if at all, is LCC-RyR intermolecular failure logically linked to the global performance of E-C coupling?
Regulation (intermolecular) of LCC
2) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.47 Pain Relevance 0.05
To understand the modification of LCC-RyR coupling efficiency, the following aspects need to be considered:
Regulation (modification) of LCC
3) Confidence 0.44 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.61 Pain Relevance 0.07
In addition to regulating Sox-2, Wnt-?
Regulation (regulating) of Sox-2
4) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.09 Pain Relevance 0.04
Decreases in the expression levels of Pax6, Hes1, nestin, and Sox2 suggest that the immature RPCs had begun undergoing differentiation toward more mature states while co-cultured on the polymer scaffolds.
Regulation (Decreases) of Sox2
5) Confidence 0.33 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Therefore, targeting pluripotency-associated molecules such as Myc and Sox2, combined with reactivation of p53, specifically in brain tumor stem cell populations could become one approach to effectively reduce tumor growth.
Regulation (targeting) of Sox2 in stem cell associated with cancer and brain tumor
6) Confidence 0.12 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.96 Pain Relevance 0

General Comments

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