INT201150

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.63
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 96.64 Very High Very High Very High
Action potential 25 92.76 High High
imagery 34 88.08 High High
tolerance 3 83.92 Quite High
fibrosis 3 61.68 Quite High
tetrodotoxin 21 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 240 98.56 Very High Very High Very High
Myocardial Infarction 81 89.00 High High
Targeted Disruption 3 76.88 Quite High
Hypertension 6 76.48 Quite High
Epilepsy 32 65.04 Quite High
Dilated Cardiomyopathy 3 64.04 Quite High
Fibrosis 3 61.68 Quite High
Convulsion 49 58.52 Quite High
Partial Seizures 8 20.60 Low Low
Cv Unclassified Under Development 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Efficiency of LCC-RyR coupling: The degraded E-C coupling gain with unchanged ICa and Ca2+ sparks lead to the idea that the efficiency of the LCC current to activate RyR Ca2+ release may be decreased [13].
Protein_catabolism (degraded) of Ca2
1) Confidence 0.75 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.73 Pain Relevance 0.09
For DHT, our data provided the molecular interpretation that the slowed response of RyR to unitary LCC triggers results in an increased chance of failure in LCC-RyR coupling, which then leads to a degradation in intracellular Ca2+ transients.
Protein_catabolism (degradation) of Ca2 associated with hypertrophy
2) Confidence 0.75 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 1.07 Pain Relevance 0.03
We performed whole-cell voltage-clamp experiments and dialyzed into the cell 10 mM EGTA, a slow Ca2+ buffer that suppresses the spatiotemporal integral of Ca2+ without interfering with CICR [19,20].
Protein_catabolism (integral) of Ca2
3) Confidence 0.75 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.41 Pain Relevance 0.04
Slices were recovered for 15 min at 37°C and then loaded with the Ca2+-sensitive dye OGB1-AM (Invitrogen) for 60 min at 37°C.
Protein_catabolism (loaded) of Ca2
4) Confidence 0.31 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.42 Pain Relevance 0.05

General Comments

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